Increasing non-cosmetic exposure and sensitization to isothiazolinones require action for prevention: Review.
Contact Dermatitis
; 90(5): 445-457, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38382085
ABSTRACT
Frequent use of methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and MI in cosmetic products has been the main cause of widespread sensitization and allergic contact dermatitis to these preservatives (biocides). Their use in non-cosmetic products is also an important source of sensitization. Less is known about sensitization rates and use of benzisothiazolinone (BIT), octylisothiazolinone (OIT), and dichlorooctylisothiazolinone (DCOIT), which have never been permitted in cosmetic products in Europe. BIT and OIT have occasionally been routinely patch-tested. These preservatives are often used together in chemical products and articles. In this study, we review the occurrence of contact allergy to MI, BIT, OIT, and DCOIT over time, based on concomitant patch testing in large studies, and case reports. We review EU legislations, and we discuss the role of industry, regulators, and dermatology in prevention of sensitization and protection of health. The frequency of contact allergy to MI, BIT, and OIT has increased. The frequency of contact allergy to DCOIT is not known because it has seldom been patch-tested. Label information on isothiazolinones in chemical products and articles, irrespective of concentration, is required for assessment of relevance, information to patients, and avoidance of exposure and allergic contact dermatitis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
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Dermatite Alérgica de Contato
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Cosméticos
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Desinfetantes
Limite:
Humans
País/Região como assunto:
Europa
Idioma:
En
Revista:
Contact Dermatitis
/
Contact dermat
/
Contact dermatitis
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suécia