Collagenase Clostridium histolyticum for Peyronie's disease: a contemporary atlas of complications and their management.
Sex Med Rev
; 12(3): 491-496, 2024 Jun 26.
Article
em En
| MEDLINE
| ID: mdl-38491199
ABSTRACT
INTRODUCTION:
Collagenase Clostridium histolyticum (CCH) remains the only Food and Drug Administration-approved medical treatment for Peyronie's disease (PD). The initial IMPRESS I and II trials (Investigation for Maximal Peyronie's Reduction Efficacy and Safety), which led to Food and Drug Administration approval, revealed a rate of treatment-related adverse events as high as 84%. Studies fail to provide clear definitions of complications.OBJECTIVES:
To review complications, provide a CCH complication atlas, and propose management strategies for commonly encountered complications.METHODS:
We performed a literature review using PubMed. A photographic atlas was provided regarding complications in patients in a high-volume CCH center for PD.RESULTS:
Complications were identified and classified by nature and severity. We followed a standardized previously published grading system for hematomas. Complications include bruising, swelling, hematoma formation, back pain, and, rarely, corporal rupture. Complications were discussed, and hematomas were graded by penile surface area. Complication photographs were graded and displayed. Treatment-related adverse effects do not affect overall results.CONCLUSION:
Recognizing and grading complications associated with CCH therapy for PD is crucial for effective patient management and informed decision making. A standardized grading system allows for consistency in reporting and comparing hematoma complication rates across studies and patient populations. Herein we provide images that will help clinicians identify and confidently manage common complications that may occur in any CCH program.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Induração Peniana
/
Colagenase Microbiana
Limite:
Humans
/
Male
Idioma:
En
Revista:
Sex Med Rev
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos