Your browser doesn't support javascript.
loading
Structural and resting-state connection abnormalities of habenula in obsessive-compulsive disorder.
Liu, Qian; Wang, Xiang; Cao, Yanyuan; Gao, Feng; Xia, Jie; Du, Hongyu; Liao, Haiyan; Tan, Changlian; Fan, Jie; Zhu, Xiongzhao.
Afiliação
  • Liu Q; Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Wang X; Medical Psychological Institute of Central South University, Changsha, Hunan, China.
  • Cao Y; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
  • Gao F; Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Xia J; Medical Psychological Institute of Central South University, Changsha, Hunan, China.
  • Du H; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
  • Liao H; Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
  • Tan C; Medical Psychological Institute of Central South University, Changsha, Hunan, China.
  • Fan J; National Clinical Research Center for Mental Disorders, Changsha, Hunan, China.
  • Zhu X; Medical Psychological Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Psychol Med ; 54(9): 2283-2290, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38515276
ABSTRACT

BACKGROUND:

Previous studies have suggested that the habenula (Hb) may be involved in the mechanism of obsessive-compulsive disorder (OCD). However, the specific role of Hb in OCD remains unclear. This study aimed to explore the structural and functional abnormalities of Hb in OCD and their relationship with the clinical symptoms.

METHODS:

Eighty patients with OCD and 85 healthy controls (HCs) were recruited as the primary dataset. The grey matter volume, resting-state functional connectivity (FC), and effective connectivity (EC) of the Hb were calculated and compared between OCD group and HCs. An independent replication dataset was used to verify the stability and robustness of the results.

RESULTS:

Patients with OCD exhibited smaller Hb volume and increased FC of right Hb-left hippocampus than HCs. Dynamic causal model revealed an increased EC from left hippocampus to right Hb and a less inhibitory causal influence from the right Hb to left hippocampus in the OCD group compared to HCs. Similar results were found in the replication dataset.

CONCLUSIONS:

This study suggested that abnormal structure of Hb and hippocampus-Hb connectivity may contribute to the pathological basis of OCD.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Habenula / Hipocampo / Transtorno Obsessivo-Compulsivo Limite: Adult / Female / Humans / Male Idioma: En Revista: Psychol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Habenula / Hipocampo / Transtorno Obsessivo-Compulsivo Limite: Adult / Female / Humans / Male Idioma: En Revista: Psychol Med Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China