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External validation of the SI2NCAL2C score for outcomes following cerebral venous thrombosis.
Klein, Piers; Shu, Liqi; Lindgren, Erik; de Winter, Maria A; Siegler, James E; Simpkins, Alexis N; Omran, Satareh Salehi; Heldner, Mirjam R; de Havenon, Adam; Abdalkader, Mohamad; Al Kasab, Sami; Stretz, Christoph; Wu, Teddy Y; Wilson, Duncan; Asad, Syed Daniyal; Almallouhi, Eyad; Frontera, Jennifer; Kuohn, Lindsey; Rothstein, Aaron; Bakradze, Ekaterina; Henninger, Nils; Zubair, Adeel S; Sharma, Richa; Kerrigan, Deborah; Aziz, Yasmin; Mistry, Eva A; van Kammen, Mayte Sanchez; Tatlisumak, Turgut; Krzywicka, Katarzyna; Aguiar de Sousa, Diana; Jood, Katarina; Field, Thalia S; Yaghi, Shadi; Coutinho, Jonathan M; Nguyen, Thanh N.
Afiliação
  • Klein P; Department of Neurology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, 725 Albany St. Suite 7B, Boston, MA 02118, United States.
  • Shu L; Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
  • Lindgren E; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • de Winter MA; Department of Internal Medicine, UMC Utrecht, and Department of Internal Medicine, Diakonessenhuis, Utrecht, The Netherlands.
  • Siegler JE; Department of Neurology, Cooper Neurological Institute, Cooper University Hospital, Camden, NJ, United States; Department of Neurology, University of Chicago, United States.
  • Simpkins AN; Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States; Department of Neurology, University of Florida, Gainesville, FL, United States.
  • Omran SS; Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, United States.
  • Heldner MR; Department of Neurology and Stroke Research Center Bern, University of Bern and University Hospital Bern, Bern, Switzerland.
  • de Havenon A; Department of Neurology, Yale University, New Haven, CT, United States.
  • Abdalkader M; Department of Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, United States.
  • Al Kasab S; Department of Neurology and Neurosurgery, Medical University of South Carolina, Charleston, SC, United States.
  • Stretz C; Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
  • Wu TY; Department of Neurology, Christchurch Hospital, Christchurch, New Zealand.
  • Wilson D; Department of Neurology, Christchurch Hospital, Christchurch, New Zealand.
  • Asad SD; Department of Neurology, Hartford Hospital, Hartford, CT, United States.
  • Almallouhi E; Department of Neuroscience, Sarasota Memorial Hospital, Sarasota, FL, United States.
  • Frontera J; Department of Neurology, New York University, New York, NY, United States.
  • Kuohn L; Department of Neurology, New York University, New York, NY, United States.
  • Rothstein A; Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States.
  • Bakradze E; Department of Neurology, University of Alabama at Birmingham, Birmingham, AL, United States.
  • Henninger N; Departments of Neurology and Psychiatry, University of Massachusetts Chan Medical School, Worcester, MA, United States.
  • Zubair AS; Department of Neurology, Yale University, New Haven, CT, United States.
  • Sharma R; Department of Neurology, Yale University, New Haven, CT, United States.
  • Kerrigan D; Department of Neurology, Vanderbilt University, Nashville, TN, United States.
  • Aziz Y; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, United States.
  • Mistry EA; Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, United States.
  • van Kammen MS; Department of Neurology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, The Netherlands.
  • Tatlisumak T; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Krzywicka K; Department of Neurology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, The Netherlands.
  • Aguiar de Sousa D; Stroke Center, Centro Hospitalar Universitário Lisboa Central - ULS São José, and Instituto de Medicina Molecular and Instituto de Anatomia, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
  • Jood K; Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg and Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden.
  • Field TS; Division of Neurology and Vancouver Stroke Program, University of British Columbia, Vancouver, Canada.
  • Yaghi S; Department of Neurology, The Warren Alpert Medical School of Brown University, Providence, RI, United States.
  • Coutinho JM; Department of Neurology, Amsterdam University Medical Centers, location University of Amsterdam, Amsterdam, The Netherlands.
  • Nguyen TN; Department of Neurology, Boston Medical Center, Boston University Chobanian & Avedisian School of Medicine, 725 Albany St. Suite 7B, Boston, MA 02118, United States; Department of Radiology, Boston Medical Center, Boston University Chobanian and Avedisian School of Medicine, United States. Elect
J Stroke Cerebrovasc Dis ; 33(6): 107720, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38614162
ABSTRACT

OBJECTIVES:

Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2NCAL2C score in an international cohort. MATERIALS AND

METHODS:

The SI2NCAL2C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2NCAL2C score uses 9 variables the absence of any female-sex-specific risk factors, intracerebral hemorrhage, central nervous system infection, focal neurological deficits, coma, age, lower level of hemoglobin, higher level of glucose, and cancer. The ACTION-CVT study was an international retrospective study that enrolled consecutive patients across 27 centers. The poor outcome score was validated using 90-day mRS due to lack of follow-up at the 6-month time-point in the ACTION-CVT cohort. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC) and calibration plots. Missing data were imputed using the additive regression and predictive mean matching methods. Bootstrapping was performed with 1000 iterations.

RESULTS:

Mortality data were available for 950 patients and poor outcome data were available for 587 of 1,025 patients enrolled in ACTION-CVT. Compared to the International CVT Consortium, the ACTION-CVT cohort was older, less often female, and with milder clinical presentation. Mortality was 2.5% by 30 days and 6.0% by one year. At 90-days, 16.7% had a poor outcome. The SI2NCAL2C score had an AUC of 0.74 [95% CI 0.69-0.79] for 90-day poor outcome, 0.72 [0.60-0.82] for mortality by 30 days, and 0.82 [0.76-0.88] for mortality by one year.

CONCLUSIONS:

The SI2NCAL2C score had acceptable to good performance in an international external validation cohort. The SI2NCAL2C score warrants additional validation studies in diverse populations and clinical implementation studies.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valor Preditivo dos Testes / Trombose Venosa / Trombose Intracraniana / Avaliação da Deficiência / Estado Funcional Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Assunto da revista: ANGIOLOGIA / CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Valor Preditivo dos Testes / Trombose Venosa / Trombose Intracraniana / Avaliação da Deficiência / Estado Funcional Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Stroke Cerebrovasc Dis Assunto da revista: ANGIOLOGIA / CEREBRO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos