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Frizzled receptors (FZDs) in Wnt signaling: potential therapeutic targets for human cancers.
Liu, Hui-Yu; Sun, Xiao-Jiao; Xiu, Si-Yu; Zhang, Xiang-Yu; Wang, Zhi-Qi; Gu, Yan-Lun; Yi, Chu-Xiao; Liu, Jun-Yan; Dai, Yu-Song; Yuan, Xia; Liao, Hua-Peng; Liu, Zhen-Ming; Pang, Xiao-Cong; Li, Tian-Cheng.
Afiliação
  • Liu HY; Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.
  • Sun XJ; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Xiu SY; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Zhang XY; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Wang ZQ; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Gu YL; Department of Pharmacy, Peking University First Hospital, Beijing, 100034, China.
  • Yi CX; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Liu JY; Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.
  • Dai YS; Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China.
  • Yuan X; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
  • Liao HP; Yizhang County People's Hospital, Chenzhou, 424200, China.
  • Liu ZM; State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China. zmliu@bjmu.edu.cn.
  • Pang XC; Department of Pharmacy, Peking University First Hospital, Beijing, 100034, China. pangxiaocong1227@163.com.
  • Li TC; Department of Otorhinolaryngology Head and Neck Surgery, Peking University First Hospital, Beijing, 100034, China. litiancheng@bjmu.edu.cn.
Acta Pharmacol Sin ; 45(8): 1556-1570, 2024 Aug.
Article em En | MEDLINE | ID: mdl-38632318
ABSTRACT
Frizzled receptors (FZDs) are key contributors intrinsic to the Wnt signaling pathway, activation of FZDs triggering the Wnt signaling cascade is frequently observed in human tumors and intimately associated with an aggressive carcinoma phenotype. It has been shown that the abnormal expression of FZD receptors contributes to the manifestation of malignant characteristics in human tumors such as enhanced cell proliferation, metastasis, chemotherapy resistance as well as the acquisition of cancer stemness. Given the essential roles of FZD receptors in the Wnt signaling in human tumors, this review aims to consolidate the prevailing knowledge on the specific status of FZD receptors (FZD1-10) and elucidate their respective functions in tumor progression. Furthermore, we delineate the structural basis for binding of FZD and its co-receptors to Wnt, and provide a better theoretical foundation for subsequent studies on related mechanisms. Finally, we describe the existing biological classes of small molecule-based FZD inhibitors in detail in the hope that they can provide useful assistance for design and development of novel drug candidates targeted FZDs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Frizzled / Via de Sinalização Wnt / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Receptores Frizzled / Via de Sinalização Wnt / Neoplasias / Antineoplásicos Limite: Animals / Humans Idioma: En Revista: Acta Pharmacol Sin Assunto da revista: FARMACOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China