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Two New Phenylpropanoid Compounds from Lilium Brownii and Their Anti-monoamine Oxidase Activity.
Hui, Chengcheng; He, Shuaibo; Ji, Mengshan; Zhang, Yuhang; Wang, Haibo; Wang, Xiaowei; Guo, Tao.
Afiliação
  • Hui C; Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China Tel.
  • He S; Henan Engineering Research Center of Medicinal and Edible Chinese Medicine, Zhengzhou, 450046, China.
  • Ji M; Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China Tel.
  • Zhang Y; Department of Pharmacy, Henan University of Chinese Medicine, Zhengzhou, 450046, China Tel.
  • Wang H; Henan Engineering Research Center of Medicinal and Edible Chinese Medicine, Zhengzhou, 450046, China.
  • Wang X; The Second Clinical Medical College, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
  • Guo T; NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine (Chinese Materia Medica and prepared slices), Henan Institute for Drug and Medical Device Inspection (Henan Vaccine Issuance Center), Zhengzhou, 450018, China.
Chem Biodivers ; 21(6): e202400524, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38634793
ABSTRACT
Baihe is a commonly used Chinese medicine for the treatment of neurological disorders. Clinically, the bulbs of Lilium brownii are used to act as Baihe. In the study, two new phenylpropanoid compounds including 3-O-acetyl-1-O-caffeoylglycerol (1) and 3-O-acetyl-1-O-p-coumaroylglycerol (2) were isolated from the bulbs of L. brownii. Their structures were identified by spectroscopic method and the effect on monoamine oxidase activity was determined using an enzyme labeling method. The results show 1 and 2 have anti-monoamine oxidase activity with 20.96 % and 22.31 % inhibition rates at 50 µg/ml, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lilium / Monoaminoxidase / Inibidores da Monoaminoxidase Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Lilium / Monoaminoxidase / Inibidores da Monoaminoxidase Idioma: En Revista: Chem Biodivers Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2024 Tipo de documento: Article