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Blue light irradiation inhibits the M2 polarization of the cancer-associated macrophages in colon cancer.
Yoshimoto, Toshiaki; Nishi, Masaaki; Okikawa, Shohei; Yoshikawa, Kozo; Tokunaga, Takuya; Nakao, Toshihiro; Takasu, Chie; Kashihara, Hideya; Wada, Yuma; Noma, Takayuki; Shimada, Mitsuo.
Afiliação
  • Yoshimoto T; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan. yoshimoto.toshiaki@tokushima-u.ac.jp.
  • Nishi M; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Okikawa S; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Yoshikawa K; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Tokunaga T; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Nakao T; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Takasu C; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Kashihara H; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Wada Y; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Noma T; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
  • Shimada M; Department of Surgery, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima City, 770-8503 Tokushima, Japan.
BMC Cancer ; 24(1): 664, 2024 May 31.
Article em En | MEDLINE | ID: mdl-38822331
ABSTRACT
Recent studies have shown that blue light-emitting diode (LED) light has anti-tumor effects, suggesting the possibility of using visible light in cancer therapy. However, the effects of blue light irradiation on cells in the tumor microenvironment, including tumor-associated macrophages (TAMs), are unknown. Here, THP-1 cells were cultured in the conditioned medium (CM) of HCT-116 cells to prepare TAMs. TAMs were divided into LED-irradiated and control groups. Then, the effects of blue LED irradiation on TAM activation were examined. Expression levels of M2 macrophage markers CD163 and CD206 expression were significantly decreased in LED-irradiated TAMs compared with the control group. While control TAM-CM could induce HCT-116 cell migration, these effects were not observed in cells cultured in TAM-CM with LED irradiation. Vascular endothelial growth factor (VEGF) secretion was significantly suppressed in LED-exposed TAMs. PD-L1 expression was upregulated in HCT-116 cells cultured with TAM-CM but attenuated in cells cultured with LED-irradiated TAM-CM. In an in vivo model, protein expression levels of F4/80 and CD163, which are TAM markers, were reduced in the LED-exposed group. These results indicate that blue LED light may have an inhibitory effect on TAMs, as well as anti-tumor effects on colon cancer cells.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Macrófagos Associados a Tumor / Luz Azul Limite: Animals / Humans Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Macrófagos Associados a Tumor / Luz Azul Limite: Animals / Humans Idioma: En Revista: BMC Cancer Assunto da revista: NEOPLASIAS Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Japão