Isoforms of terminal selector Mamo control axon guidance during adult Drosophila memory center construction via Semaphorin-1a.
Dev Biol
; 515: 1-6, 2024 Nov.
Article
em En
| MEDLINE
| ID: mdl-38906235
ABSTRACT
In animals undergoing metamorphosis, the appearance of the nervous system is coincidently transformed by the morphogenesis of neurons. Such morphogenic alterations are exemplified in three types of intrinsic neurons in the Drosophila memory center. In contrast to the well-characterized remodeling of γ neurons, the morphogenesis of α/ß and α'/ß' neurons has not been adequately explored. Here, we show that mamo, a BTB-zinc finger transcription factor that acts as a terminal selector for α'/ß' neurons, controls the formation of the correct axonal pattern of α'/ß' neurons. Intriguingly, specific Mamo isoforms are preferentially expressed in α'/ß' neurons to regulate the expression of axon guidance molecule Semaphorin-1a. This action directs proper axon guidance in α'/ß' neurons, which is also crucial for wiring of α'/ß' neurons with downstream neurons. Taken together, our results provide molecular insights into how neurons establish correct axonal patterns in circuitry assembly during adult memory center construction.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Isoformas de Proteínas
/
Proteínas de Drosophila
/
Semaforinas
/
Orientação de Axônios
/
Memória
Limite:
Animals
Idioma:
En
Revista:
Dev Biol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Taiwan