Development of Myelin Growth Charts of the White Matter Using T1 Relaxometry.
AJNR Am J Neuroradiol
; 2024 Jul 18.
Article
em En
| MEDLINE
| ID: mdl-39025639
ABSTRACT
BACKGROUND AND PURPOSE:
Myelin maturation occurs in late fetal life to early adulthood, with the most rapid changes observed in the first few years of infancy. To quantify the degree of myelination, a specific MR imaging sequence is required to measure the changes in tissue proton relaxivity (R1). R1 positively correlates with the degree of myelination maturation at a given age. Similar to head circumference charts, these data can be used to develop normal growth charts for specific white matter tracts to detect pathologies involving abnormal myelination. MATERIALS ANDMETHODS:
This is a cross-sectional study using normal clinical pediatric brain MR images with the MP2RAGE sequence to generate T1 maps. The T1 maps were segmented to 75 brain regions from a brain atlas (white matter and gyri). Statistical modeling for all subjects across regions and the age range was computed, and estimates of population-level percentile ranking were computed to describe the effective myelination rate as a function of age. Test-retest analysis was performed to assess reproducibility. Logistic trendline and regression were performed for selected white matter regions and plotted for growth charts.RESULTS:
After exclusion for abnormal MR imaging or diseases affecting myelination from the electronic medical record, 103 subject MR images were included, ranging from birth to 17 years of age. Test-retest analysis resulted in a high correlation for white matter (r = 0.88) and gyri (r = 0.95). All white matter regions from the atlas had significant P values for logistic regression with R 2 values ranging from 0.41 to 0.99.CONCLUSIONS:
These data can serve as a myelination growth chart to permit patient comparisons with normal levels with respect to age and brain regions, thus improving detection of developmental disorders affecting myelin.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Ano de publicação:
2024
Tipo de documento:
Article