Physical activity, long-term fine particulate matter exposure and type 2 diabetes incidence: A prospective cohort study.
Chronic Dis Transl Med
; 10(3): 205-215, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-39027196
ABSTRACT
Background:
Despite the adverse effects of ambient fine particulate matter (PM2.5) on type 2 diabetes and the beneficial role of physical activity (PA), the influence of PM2.5 on the relationship between PA and type 2 diabetes remains unclear.Methods:
In this prospective study with 71,689 participants, PA was assessed by a questionnaire and was categorized into quartiles for volume and three groups for intensity. Long-term PM2.5 exposure was calculated using 1-km resolution satellite-based PM2.5 estimates. PM2.5 exposure and PA's effect on type 2 diabetes were assessed by cohort-stratified Cox proportional hazards models, individually and in combination.Results:
In 488,166 person-years of follow-up, 5487 incident type 2 diabetes cases were observed. The association between PA and type 2 diabetes was modified by PM2.5. Compared with the lowest quartile of PA volume, the highest quartile was associated with reduced type 2 diabetes risk in low PM2.5 stratification (≤65.02 µg/m3) other than in high PM2.5 stratification (>65.02 µg/m3), with the hazard ratio (HR) of 0.75 (95% confidence interval [CI] 0.66-0.85) and 1.10 (95% CI 0.99-1.22), respectively. Similar results were observed for PA intensity. High PM2.5 exposure combined with the highest PA levels increased the risk of type 2 diabetes the most (HR = 1.79, 95% CI 1.59-2.01 for PA volume; HR = 1.82, 95% CI 1.64-2.02 for PA intensity).Conclusion:
PA could reduce type 2 diabetes risk in low-pollution areas, but high PM2.5 exposure may weaken or even reverse the protective effects of PA. Safety and health benefits of PA should be thoroughly assessed for long-term polluted residents.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Chronic Dis Transl Med
Ano de publicação:
2024
Tipo de documento:
Article