Antimalarials V: aminobenzothiazoles.
J Pharm Sci
; 65(4): 618-20, 1976 Apr.
Article
em En
| MEDLINE
| ID: mdl-775054
ABSTRACT
Four mono- and dialkylated 4-aminobenzothiazoles (VII-X) were prepared as analogs of potent causal prophylactic drugs in the 8-aminoquinoline series. Compounds VII and VIII were toxic at 80 mg/kg in the chick; IX was inactive at 640 mg/kg. In a sporozoite-induced mouse test system, X was inactive at 30 mg/kg and toxic at 480 mg/kg. None of the compounds was active as a suppressive drug.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Antimaláricos
Limite:
Animals
Idioma:
En
Revista:
J Pharm Sci
Ano de publicação:
1976
Tipo de documento:
Article