Emetic activity of N-substituted norapomorphines.
J Med Chem
; 18(10): 1000-3, 1975 Oct.
Article
em En
| MEDLINE
| ID: mdl-808605
ABSTRACT
Norapomorphine and ten of its N-substituted derivatives were prepared by modifications of procedures described earlier. In a dog emesis test the N-ethyl and N-n-propyl compounds had minimum effective doses of 0.00025 and 0.0005 mg/kg, respectively, when administered iv, sc, or im. In a modified Irwin mouse profile screen the minimum effective iv dose was 0.013 mg/kg for the N-ethyl and 0.0024 mg/kg for the N-n-propyl compound; percutaneous absorption was also observed in mice. All compounds examined caused the stereotyped apomorphine behavior syndrome but hypotensive effects were not serious.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apomorfina
/
Eméticos
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Med Chem
Assunto da revista:
QUIMICA
Ano de publicação:
1975
Tipo de documento:
Article