Radioimmunoassay of serum myelin basic protein and its application to patients with cerebrovascular accident.
Clin Chim Acta
; 92(3): 403-9, 1979 Mar 15.
Article
em En
| MEDLINE
| ID: mdl-86395
ABSTRACT
Myelin basic protein-like immunoactivity was measured in the serum of patients after cerebrovascular accident (CVA) using a double antibody radioimmunoassay for myelin basic protein with a detection limit of 3 ng/ml serum. For up to 6 days after ictus, serum myelin basic protein levels in patients with severe CVA and patients who died as a result of CVA were significantly greater than those in control patients, patients with moderate CVA and patients surviving CVA. All patients with serum myelin basic protein levels greater than the range found in control subjects subsequently died. Serial dilutions of positive sera suggested that the immunoactivity differs from authentic myelin basic protein and may represent breakdown products of the protein. Serum from some patients with a previous history of moderate CVA had myelin basic protein binding activity consistent with the presence of antibodies to the protein.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transtornos Cerebrovasculares
/
Proteína Básica da Mielina
Limite:
Humans
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
1979
Tipo de documento:
Article