Syntheses and antifungal activity of dl-griseofulvin and its congeners. II.
Chem Pharm Bull (Tokyo)
; 45(2): 327-32, 1997 Feb.
Article
em En
| MEDLINE
| ID: mdl-9118447
ABSTRACT
Griseofulvin derivatives, dl-6'-demethyl-6'-ethylgriseofulvin (dl-5) and dl-6'demethyl-6'phenylgriseofulvin (dl-6) were prepared by application of a synthetic method developed by us. Antifungal activity of these derivatives decreased in the order of dl-griseofulvin (dl-1) >> dl-6(inactive). The reaction of these derivatives with ethanethiol gave two types of compounds, 2'-(ethylthio)griseofulvin (15) and 4'-(ethylthio)isogriseofulvin (16). The relationship between the ratios of isolated yield of 15 and 16 and antifungal the activity of griseofulvin derivatives is discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Griseofulvina
/
Antifúngicos
Idioma:
En
Revista:
Chem Pharm Bull (Tokyo)
Ano de publicação:
1997
Tipo de documento:
Article
País de afiliação:
Japão