RESUMO
A 68-year-old woman was referred to our hospital for progressive dizziness, gait disturbances and weight loss for 18 months. The patient was alert and showed dysphagia and a marked tendency to fall backward. Electronystagmography showed bilateral vestibular dysfunction and audiometry showed right sensorineural hearing disturbance. Cerebrospinal fluid exam showed mononuclear pleocytosis and elevated protein levels. On 18F-FDG PET/CT, abnormal uptake was observed in the mediastinal lymph nodes, from which biopsy specimens were obtained. Histological findings showed non-caseous granuloma and a diagnosis of bilateral vestibulocochlear, glossopharyngeal and vagal nerve palsies due to neurosarcoidosis was made. Steroid therapy resulted in improvement in her clinical symptoms. Neurosarcoidosis should be included in the differential diagnosis of patients showing progressive easy falling and dysphagia.
Assuntos
Acidentes por Quedas , Doenças do Sistema Nervoso Central/complicações , Doenças do Sistema Nervoso Central/diagnóstico , Transtornos de Deglutição/etiologia , Fragilidade/etiologia , Sarcoidose/complicações , Sarcoidose/diagnóstico , Idoso , Doenças do Sistema Nervoso Central/tratamento farmacológico , Doenças do Sistema Nervoso Central/patologia , Diagnóstico Diferencial , Feminino , Humanos , Leucocitose/etiologia , Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada , Prednisolona/administração & dosagem , Sarcoidose/tratamento farmacológico , Sarcoidose/patologia , Resultado do TratamentoRESUMO
A 26-year-old, otherwise healthy man presented with visual abnormality followed by loss of consciousness and convulsion. The patient then developed headache and fever 14 days later. Brain MRI showed hyperintensities in the left cingulate cortex. The cerrebrospinal fluid examinations showed mononuclear pleocytosis and positive PCR results for human herpesvirus 6 (HHV-6). A diagnosis of HHV-6 encephalitis and symptomatic epilepsy was made. The patient's clinical symptoms improved promptly following acyclovir treatment. However, 3 months later the patient noticed dysesthesia in the trunk, the left upper limb and the right lower limb. Brain and spine MRI showed multiple brain white matter lesions, the middle cerebellar peduncle and cervical spinal lesions. The symptoms resolved following methylprednisolone pulse therapy only. We report an adult patient with HHV-6 encephalitis followed by acute disseminated encephalomyelitis whose initial presentation was epilepsy. HHV-6 encephalitis should be included in the differential diagnosis of encephalitis of unknown etiology in an immunocompetent adult.
Assuntos
Encefalite/diagnóstico , Encefalite/virologia , Encefalomielite Aguda Disseminada/etiologia , Herpesvirus Humano 6/isolamento & purificação , Imunocompetência , Infecções por Roseolovirus , Adulto , Biomarcadores/líquido cefalorraquidiano , Encéfalo/diagnóstico por imagem , Vértebras Cervicais , Encefalite/tratamento farmacológico , Encefalomielite Aguda Disseminada/tratamento farmacológico , Epilepsia/tratamento farmacológico , Epilepsia/etiologia , Humanos , Imageamento por Ressonância Magnética , Masculino , Metilprednisolona/administração & dosagem , Pulsoterapia , Medula Espinal/diagnóstico por imagem , Resultado do TratamentoRESUMO
A 70-year-old woman noticed difficulty in speech and weakness of the left upper and lower limb upon awakening. Neurological examination showed dysarthria and left hemiparesis. No sensory disturbance was observed. Brain MRI revealed acute infarction in the right posterior limb of the internal capsule. On the hospital day 1, she developed the abnormal sensations restricted to the bilateral shoulders, resulting in difficulty initiating sleep. On laboratory data, renal function and serum hemoglobin and ferritin levels were normal. When four essential features of restless legs syndrome (RLS) were applied to her shoulders, the patient met RLS criteria. Following low dose pramipexole treatment, the abnormal sensation of the shoulders and insomnia significantly improved. We should be aware of the possibility of RLS or its variant, including "restless shoulder" of our patient, for the cause of insomnia following acute ischemic infarction.