RESUMO
UNLABELLED: Lafutidine is a unique histamine H(2)-receptor antagonist (H2RA) that has a sensitizing effect on capsaicin-sensitive afferent neurons (CSAN). This effect may make lafutidine useful for the treatment of burning mouth syndrome (BMS). METHODS: To evaluate the efficacy and safety of lafutidine in patients with oral burning sensation, a randomized controlled trial was performed. Patients who had been receiving other H2RAs with no sensitizing effect on CSAN were randomly assigned to receive lafutidine 10 mg twice daily for 12 weeks, instead of the previous H2RAs, plus gargling with azulene sulfonate sodium (ASS) (lafutidine group, n = 36) or to continue to receive the previous H2RAs plus ASS gargling (control group, n = 35). The intensity of burning sensation was scored by means of a visual analog scale (VAS). RESULTS: Thirty-four patients in the lafutidine group and 30 in the control group completed the study. In the lafutidine group, the rate of improvement in the VAS score as compared with the baseline value was significant after 4, 8, and 12 weeks of treatment (P < 0.05). The improvement rate was consistently higher in the lafutidine group than in the control group; the differences between the groups were significant (P < 0.05) after 4, 8, and 12 weeks of treatment. Only two mild abdominal adverse events occurred in the lafutidine group, but neither required the termination of treatment. CONCLUSION: Oral lafutidine is very safe and effective for reducing the intensity of oral burning sensation and may therefore be a viable option for the treatment of BMS.
Assuntos
Acetamidas/uso terapêutico , Síndrome da Ardência Bucal/tratamento farmacológico , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Piperidinas/uso terapêutico , Piridinas/uso terapêutico , Acetamidas/farmacologia , Idoso , Capsaicina/farmacologia , Feminino , Antagonistas dos Receptores H2 da Histamina/farmacologia , Humanos , Masculino , Neurônios Aferentes/efeitos dos fármacos , Medição da Dor , Cuidados Paliativos , Piperidinas/farmacologia , Piridinas/farmacologia , Fármacos do Sistema Sensorial/farmacologia , Resultado do TratamentoRESUMO
A simple and easy cryosurgical method to treat intraoral mucous cysts is described. Twelve female and six male patients, with mucous cysts on the lower lip and the tip of the tongue, were treated by direct application of liquid nitrogen with a cotton swab. Each lesion was exposed to four or five cycles composed of freezings of 10-30 s and thawings of double the freezing times. No anesthesia was required. All lesions had disappeared completely 2-4 weeks after one or two treatment courses of cryosurgery. In all cases, neither scarring nor recurrence was noted during the 6 months to 5 years of follow-up.