Choline prevents cardiac hypertrophy by inhibiting protein kinase C-Î´ dependent transient receptor potential canonical 6 channel.

Qi, Jiancui; Tian, Shanshan; Zhang, Zhihua; Zha, Chuanqin; Zhang, Yong; Hang, Pengzhou; Du, Zhimin

Qi, Jiancui; Tian, Shanshan; Zhang, Zhihua; Zha, Chuanqin; Zhang, Yong; Hang, Pengzhou; Du, Zhimin.

Afiliação

Qi J; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Tian S; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Zhang Z; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Zha C; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China.
Zhang Y; Department of Pharmacology, Harbin Medical University, Harbin, 150081, Heilongjiang Province, China.
Hang P; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China; Key Laboratory of Drug Research, Harbin Medical University, Heilongjiang Higher Education Institutions, Harbin 150086, Heilongjiang Province, China.
Du Z; Institute of Clinical Pharmacy, The Second Affiliated Hospital, Harbin Medical University, Harbin 150086, Heilongjiang Province, China; Key Laboratory of Drug Research, Harbin Medical University, Heilongjiang Higher Education Institutions, Harbin 150086, Heilongjiang Province, China. Electronic addr

Int J Cardiol ; 172(3): e525-6, 2014 Apr 01.

Article em En | MEDLINE | ID: mdl-24486061

Assuntos

Cardiomegalia/prevenção & controle; Colina/farmacologia; Miocárdio/metabolismo; Proteína Quinase C-delta/metabolismo; Canais de Cátion TRPC/metabolismo; Animais; Cardiomegalia/metabolismo; Cardiomegalia/patologia; Humanos; Miocárdio/patologia; Proteína Quinase C-delta/antagonistas & inibidores; Canais de Cátion TRPC/antagonistas & inibidores

Palavras-chave

Cardiac hypertrophy; Choline; Protein kinase C-Î´; Transient receptor potential canonical 6

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colina / Cardiomegalia / Proteína Quinase C-delta / Canais de Cátion TRPC / Miocárdio Limite: Animals / Humans Idioma: En Ano de publicação: 2014

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