Efficacy and safety of leflunomide treatment in Takayasu arteritis: Case series from the East China cohort.
Semin Arthritis Rheum
; 50(1): 59-65, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31350057
ABSTRACT
OBJECTIVE:
To evaluate the efficacy and safety of leflunomide (LEF) as induction treatment in a series of Takayasu arteritis (TA) patients based on a Chinese cohort.METHOD:
Fifty-six patients from the East China TA cohort treated with LEF for at least 3 months were enrolled in this study, including the naïve LEF treatment patients (nâ¯=â¯41) and the cyclophosphamide (CYC)-resistant LEF treatment patients (nâ¯=â¯15). Data in clinical features, NIH score and angiography were collected. Response to treatment was assessed by rates of complete remission (CR) and partial remission (PR) and response rate (RR) after 6 and 12 months of treatment.RESULTS:
The total CR rate and RR were 67.86% and 83.93% after 6 months, and 55.36% and 69.64% after 12 months, respectively. ESR and CRP levels and NIH scores decreased significantly after 12 months of LEF treatment (P < 0.05). Patients of CYC-resistant switched to LEF and reached the CR of 60.00% (9/15) and RR of 86.67% (13/15) after 6 months, and 73.33% (11/15) and 80.00% (12/15) after 12 months, respectively, with decrease in NIH scores (all P < 0.05). After following up for 14.44 ± 6.86 months, 48 patients (85.71%) continued LEF treatment with good tolerance. One patient died from progression of TA after 2 months, 2 patients relapsed, and 3 patients with side effects were switched to other immunosuppressive agents.CONCLUSIONS:
LEF led to a quick induction and sustained remission of TA, especially in refractory cases, and therefore, should be considered as an alternative treatment for TA.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Arterite de Takayasu
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Ciclofosfamida
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Leflunomida
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Imunossupressores
Limite:
Adolescent
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Adult
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Female
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Humans
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Male
País/Região como assunto:
Asia
Idioma:
En
Ano de publicação:
2020