Practical approaches for diagnosis and management of prurigo nodularis: United States expert panel consensus.
J Am Acad Dermatol
; 84(3): 747-760, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-32682025
ABSTRACT
BACKGROUND:
Prurigo nodularis (PN) is a chronic disease characterized by intensely pruritic, raised, nodular lesions. Because there are currently no United States Food and Drug Administration-approved therapies specifically for PN, management is highly variable, and no consensus exists on treatment regimens.OBJECTIVE:
To provide practical guidance to help United States dermatologists diagnose and effectively treat patients with PN.METHODS:
We participated in a roundtable discussion to develop consensus recommendations on diagnosis and treatment of PN from a United States perspective.RESULTS:
The core findings in PN are the presence of firm, nodular lesions; pruritus lasting at least 6 weeks; and a history or signs, or both, of repeated scratching, picking, or rubbing. The diagnostic workup involves a complete review of systems, considering potential systemic diseases, and assessment of disease severity, including disease burden and pruritus intensity. Treatment should be selected based on a patient's clinical presentation, comorbidities, and response to prior treatments and should address both neural and immunologic components of pruritus.LIMITATIONS:
Data on PN are from anecdotal or small clinical trials, and all treatments are currently used off-label.CONCLUSION:
An effective treatment approach for patients with PN should be based on clinical judgment and tailored to the individual needs of the patient.Palavras-chave
Texto completo:
1
Coleções APS:
Guias_protocolos_manuais_internacional
Base de dados:
MEDLINE
Assunto principal:
Prurigo
/
Guias de Prática Clínica como Assunto
/
Consenso
/
Fármacos Dermatológicos
Limite:
Humans
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2021