A multicentre, efficacy and safety study of methotrexate to increase response rates in patients with uncontrolled gout receiving pegloticase (MIRROR): 12-month efficacy, safety, immunogenicity, and pharmacokinetic findings during long-term extension of an open-label study.

Botson, John K; Tesser, John R P; Bennett, Ralph; Kenney, Howard M; Peloso, Paul M; Obermeyer, Katie; Song, Yang; LaMoreaux, Brian; Zhao, Lin; Xin, Yan; Chamberlain, Jason; Ramanathan, Srini; Weinblatt, Michael E; Peterson, Jeff

Botson, John K; Tesser, John R P; Bennett, Ralph; Kenney, Howard M; Peloso, Paul M; Obermeyer, Katie; Song, Yang; LaMoreaux, Brian; Zhao, Lin; Xin, Yan; Chamberlain, Jason; Ramanathan, Srini; Weinblatt, Michael E; Peterson, Jeff.

Afiliação

Botson JK; Orthopedic Physicians Alaska, 3801 Lake Otis Parkway, Suite 300, Anchorage, AK, 99508, USA. jbotson@opaak.com.
Tesser JRP; Arizona Arthritis & Rheumatology Associates, 4550 East Bell Road, Phoenix, AZ, 85032, USA.
Bennett R; Arizona Arthritis & Rheumatology Associates, 4550 East Bell Road, Phoenix, AZ, 85032, USA.
Kenney HM; Arthritis Northwest, PLLC, 105 West 8th Avenue, Suite 6080W, Spokane, WA, 99204, USA.
Peloso PM; Horizon Therapeutics Plc, 1 Horizon Way, Deerfield, IL, 60015, USA.
Obermeyer K; Horizon Therapeutics Plc, 1 Horizon Way, Deerfield, IL, 60015, USA.
Song Y; Horizon Therapeutics Plc, 2 Tower Place, South San Francisco, CA, 94080, USA.
LaMoreaux B; Horizon Therapeutics Plc, 1 Horizon Way, Deerfield, IL, 60015, USA.
Zhao L; Horizon Therapeutics Plc, 1 Horizon Way, Deerfield, IL, 60015, USA.
Xin Y; Horizon Therapeutics Plc, 2 Tower Place, South San Francisco, CA, 94080, USA.
Chamberlain J; Horizon Therapeutics Plc, 2 Tower Place, South San Francisco, CA, 94080, USA.
Ramanathan S; Horizon Therapeutics Plc, 2 Tower Place, South San Francisco, CA, 94080, USA.
Weinblatt ME; Division of Rheumatology, Inflammation and Immunity, Brigham and Women's Hospital, 75 Francis Street, Boston, MA, 02115, USA.
Peterson J; Western Washington Medical Group Arthritis Clinic, 1909 214th Street SE, Suite 211, Bothell, WA, 98021, USA.

Arthritis Res Ther ; 24(1): 208, 2022 08 25.

Article em En | MEDLINE | ID: mdl-36008814

Assuntos

Gota; Gota/tratamento farmacológico; Supressores da Gota/efeitos adversos; Humanos; Masculino; Metotrexato/uso terapêutico; Polietilenoglicóis/uso terapêutico; Exacerbação dos Sintomas; Resultado do Tratamento; Urato Oxidase/efeitos adversos; Ácido Úrico

Palavras-chave

Gout; Methotrexate; Pegloticase; Tophi

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