Infección respiratoria por bocavirus humano en lactantes de Córdoba, Argentina / Human bocavirus respiratory infection in infants in Córdoba, Argentina

Bocavirus humano (BoVh) ha sido relacionado con la infección respiratoria aguda (IRA) en los niños (prevalencia 0,9% a 33%), aunque las características clínicas aún no han sido claramente establecidas. Objetivos. Identificar la presencia de BoVh en pacientes con IRA internados en el Hospital de Niños de Córdoba y describir los casos sin coinfección detectada. Método. Se realizó la pesquisa de BoVh por PCR convencional a partir de secreciones nasales de 222 niños menores de 2 años hospitalizados por IRA durante 2011 y se registraron los datos demográficos, clínicos y radiológicos. Resultados. Se identificaron 15 pacientes BoVh+ (6,8%), con una mediana de edad de 3,5 meses (rango 1 a 22), 7/15 en coinfección (5 virus respiratorio sincicial, 1 parainfluenza-3, 1 Bordetella pertussis). Casos sin coinfección: neumonía 5/8, bronquiolitis 3/8; dos requirieron cuidados intermedios, 7/8 oxigenoterapia, 7/8 broncodilatadores, 6/8 antibióticos; enfermedad asociada 1/8 (microcefalia/cardiopatía). Conclusiones. Se identificó BoVh en 15 de 222 niños (6,8%); predominó el diagnóstico de neumonía sin casos graves ni complicaciones al alta.

It has been suggested that human bocavirus (HBoV) is related to acute respiratory infection (ARI) in children (prevalence: 0.9% to 33%) although clinical characteristics have not been clearly established yet. Objectives. To identify the presence of HBoV in patients with ARI hospitalized in Hospital de Niños de Córdoba and describe cases without co-infection. Method. HBoV screening was done by traditional PCR. Specimens to be screened were obtained from nasal secretions of 222 children under 2 years of age hospitalized due to an ARI during 2011. Demographic, clinical and radiological data were recorded. Results. Fifteen HBoV+ patients (6.8%) were identified. Their median age was 3.5 months (range: 1-22), 7/15 in co-infection (5 respiratory syncytial virus, 1 parainfluenza-3, 1 Bordetella pertussis). Cases without co-infection: pneumonia 5/8, bronchiolitis 3/8; two required intermediate care, 7/8 oxygen therapy, 7/8 bronchodilators, 6/8 antibiotics; associated disease 1/8 (microcephalus/heart disease). Conclusions. HBoV was identified in 15 out of 222 children (6.8%); the diagnosis of pneumonia was predominant without severe cases nor complications upon discharge.

Human bocavirus respiratory infection in infants in Córdoba, Argentina. / Human bocavirus respiratory infection in infants in Córdoba, Argentina.

UNLABELLED: It has been suggested that human bocavirus (HBoV) is related to acute respiratory infection (ARI) in children (prevalence: 0.9

to 33

) although clinical characteristics have not been clearly established yet. OBJECTIVES: To identify the presence of HBoV in patients with ARI hospitalized in Hospital de Niños de Córdoba and describe cases without co-infection. METHOD: HBoV screening was done by traditional PCR. Specimens to be screened were obtained from nasal secretions of 222 children under 2 years of age hospitalized due to an ARI during 2011. Demographic, clinical and radiological data were recorded. RESULTS: Fifteen HBoV+ patients (6.8

) were identified. Their median age was 3.5 months (range: 1-22), 7/15 in co-infection (5 respiratory syncytial virus, 1 parainfuenza-3, 1 Bordetella pertussis). Cases without co-infection: pneumonia 5/8, bronchiolitis 3/8; two required intermediate care, 7/8 oxygen therapy, 7/8 bronchodilators, 6/8 antibiotics; associated disease 1/8 (microcephalus/heart disease). CONCLUSIONS: HBoV was identified in 15 out of 222 children (6.8

); the diagnosis of pneumonia was predominant without severe cases nor complications upon discharge.