Displasia gastrica: su incidencia en condiciones preneoplascicas, cancer avanzado y cancer temprano

Dysplasia cancer sequence has not been determined in gastric cancer yet. Dysplastic changes are not frequent. Gastric cancer generally develops in areas of chronic atrophic gastritis. This chronic atrophic gastritis (CAG) is often associated with intestinal metaplasia (IM). IM has been classified in three types, according to morphologic patterns, differentiation and mucins production. We reviewed 55 gastrectomy specimes and 278 endoscopic biopsies. In order to determine an histological hight-risk group, we chose cases with preneoplastic conditions (60 CAG, 10 biopsies of gastric remmantes, 3 flat adenomas and 55 gastrectomies by cancer or ulcer). We also included 12 hyperplastic polyps because polyps because they may contain foci of intestinal metaplasia. Mucin techniques (PAS-ALCIAN BLUE Ph 2,5 and HID - A.B) were used in all cases that showed extensive intestinal metaplasia. In addition, we used immunohistochemistry teachniques to detect CEA. Dysplasia was found only in flat adenomas (3 cases), early gastric cancer (1 case) and advanced cancer (3 cases). We considered a preneoplastic lession only to moderate or severe dysplasia. Hyperplastic regenerative pathology is considered a reversible condition. Therefore, it should be defferentiated from dysplasia. We found that IM type III (sulfomucin predominance) is the most related to carcinoma, particulary to the intestinal type. CEA atingen is poorly specific in detecting high-risk lessions because it was seen in regenerative patology and in gastric cancer too. Relationship o f dysplasia and carcinoma, and/or neoplastic polyps was similar to other series (AU)

Displasia gástrica: su incidencia en condiciones preneoplásicas, cáncer avanzado y cáncer temprano. / [Gastric dysplasia: its incidence in precancerous conditions, advanced cancer and early cancer]

Dysplasia cancer sequence has not been determined in gastric cancer yet. Dysplastic changes are not frequent. Gastric cancer generally develops in areas of chronic atrophic gastritis. This chronic atrophic gastritis (CAG) is often associated with intestinal metaplasia (IM). IM has been classified in three types, according to morphologic patterns, differentiation and mucins production. We reviewed 55 gastrectomy specimens and 278 endoscopic biopsies. In order to determine an histological high-risk group, we chose cases with preneoplastic conditions (60 CAG, 10 biopsies of gastric remnants, 3 flat adenomas and 55 gastrectomies by cancer or ulcer). We also included 12 hyperplastic polyps because they may contain foci of intestinal metaplasia. Mucin techniques (PAS-ALCIAN BLUE Ph 2.5 and HID-A.B) were used in all cases that showed extensive intestinal metaplasia. In addition, we used immunohistochemistry techniques to detect CEA. Dysplasia was found only in flat adenomas (3 cases), early gastric cancer (1 case) and advanced cancer (3 cases). We considered a preneoplastic lesion only to moderate or severe dysplasia. Hyperplastic regenerative pathology is considered a reversible condition. Therefore, it should be differentiated from dysplasia. We found that IM type III (sulfomucin predominance) is the most related to carcinoma, particularly to the intestinal type. CEA antigen is poorly specific in detecting high-risk lesions because it was seen in regenerative pathology and in gastric cancer too. Relationship of dysplasia and carcinoma, and/or neoplastic polyps was similar to other series. Concerning to follow-up items, we agree with the concepts proposed by the Japanese Research Society for Gastric Cancer.

Experiencia con mallas de materiales heterologos como elementos sustitutivos de la pared abdominal. Polipropileno y acido poliglicolico. / Experience with a mesh of heterologous materials with replacement elements of the abdominal wall. Polypropylene and polyglycolic acid

Se presentan 35 pacientes en quienes se utilizo malla de polipropileno como elemento de reemplazo de la pared abdominal.Se analizan las complicaciones inherentes a dicho elemento y su tratamiento. Se exponen las caracteristicas y cualidades de una nueva malla reabsorbible y su aplicacion en dos observaciones, una como sustitutiva de la pared abdominal y otra como elemento de refuerzo

Analisis inmunohistoquimico y ultraestructural del tumor de Ewing. / Immunohistochemical and ultrastructural analysis of Ewings tumor

Se efectua el estudio inmunohistoquimico, mediante la tecnica de PAP (peroxidasa-antiperoxidasa) de 8 casos de tumor de Ewing, descartandose por la negatividad observada en las muestras histologicas un origen linfoide B secretor de globulinas. Los estudios ultraestructurales de 3 casos de tumor de Ewing muestran una neoplasia de aspecto cambiante, con progresiva diferenciacion desde una celula denominada predominante hasta la denominada secundaria, de mayor densidad electronica, de la que se discute su viabilidad. En cuanto a las hipotesis existentes, respecto de la estirpe celular del tumor de Ewing basadas en las observaciones ultraestructurales, no es posible abrir juicio con precision sobre la estirpe del tipo celular en cuestion, continuando vigente la hipotesis del origen histiorreticular poco diferenciado, en transformacion hacia una celula mas madura

Pancreatitis aguda necrohemorragica experimental. Nuevo enfoque terapeutico mediante la oclusion ductal con Ethibloc. / Experiental acute necrohemorrhagic pancreatits.New therapeutic approach by means of the ductal occlusion wiht ethibloc

Se presentan los resultados obtenidos a traves de la accion oclusica del gel Ethibloc, en la evolucion de una pancreatitis aguda necrohemorragica experimental procudida con cloruro de calcio en el perro. La experiencia fue hecha en dos etapas. Primero las lesiones fueron verificadas por microscopia optica y electronica.Luego de producida da pancreatitis aguda necrohemorragica, en 12 perros y en el mismo acto quirurgico, se efectuo la oclusion ductal pancreatica con el agente mencionado. Los resultados (periodo de observacion de 23 dias) fueron favorables pues se obtuvo una sobrevida del 83,3%, contra el 100% de mortalidad del grupo no tratano Se hacen consideraciones sobre los probables mecanismos de accion del Ethibloc, y se plantea la hipotesis de si futura aplicacion terapeutica en el hombre