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Hypotonic versus isotonic maintenance fluids in critically ill pediatric patients: a randomized controlled trial. / Hypotonic versus isotonic maintenance fluids in critically ill pediatric patients: a randomized controlled trial.

Jorro Barón Facundo A; Meregalli Claudia N; Rombolá Valeria A; Bolasell Cecilia; Pigliapoco Vilma E; Bartoletti Silvia E; Debaisi Gustavo E.
Arch Argent Pediatr ; 111(4): 281-7, 2013 Jul-Aug.
Artículo en Español | BINACIS | ID: bin-133044
INTRODUCTION: Hypotonic fluids have been associated with the development of iatrogenic hyponatremia. OBJECTIVES: To assess variations in serum sodium (sNa) following the intravenous administration of isotonic maintenance fluids (0.9
NaCl/5
dextrose) compared to hypotonic maintenance fluids (0.45
NaCl/5
dextrose). MATERIAL AND METHODS: Randomized, controlled, double-blind clinical trial. Pediatric patients with an expected length of stay in the intensive care unit of more than 24 hours were enrolled, with normal serum Na, and IV fluids >80
of total maintenance fluids. Serum Na level was measured before administering maintenance fluids and when reducing the administration to <80
of total fluids. RESULTS: The study included 63 patients who were randomly assigned to receive hypotonic (n= 32) or isotonic (n= 31) maintenance fluids. Baseline characteristics were similar in both groups. There were no differences in terms of volume of fluid administered (hypotonic group: 865 ± 853 mL; isotonic group: 778 ± 649 mL; p= 0.654) or infusion duration (hypotonic group: 24 ± 10.8 hours; isotonic group: 27.6 ± 12.8 hours; p= 0.231). A difference was found in the serum Na following the administration of maintenance fluids (hypotonic group: 137.8 ± 4.3 mmol/L; isotonic group: 140.0 ± 4.1 mmol/L, p= 0.04). None of these two maintenance fluids increased the risk of hyponatremia (Na 145 mmol/L). CONCLUSIONS: Neither hypotonic nor isotonic maintenance fluids increased the risk of developing iatrogenic hyponatremia with the 24 hour infusion.