Procalcitonina como biomarcador diagnóstico de sepsis en el niño con cáncer, neutropenia y fiebre: revisión de la literatura. / [Procalcitonin as a diagnostic biomarker of sepsis in children with cancer, fever and neutropenia: literature review].
Reyna-Figueroa Jesús; Lagunas-Martínez Alfredo; Martínez Matsumoto Pilar; Madrid-Marina Vicente.
Arch Argent Pediatr
; 113(1): 46-52, 2015 Jan.
Artículo
en Español
| BINACIS | ID: bin-133784
Among cancer and septic patients, there is a deregulation of common events such as inflammation. This fact limits the use of biomarkers to diagnose sepsis. Through a search in the PubMed database, we identified the clinical studies that evaluated procalcitonin as a biomarker among children with cancer and sepsis; we analyzed its characteristics, advantages and disadvantages. Most of the studies suggest that with a cut-off point between 0.5 ng/dl and 1 mg/dl, procalcitonin displays a sensitivity of 59-78
, a specificity of 76
, a predictive value of 93
and a negative predictive value of 45
to diagnose sepsis. The procalcitonin values were not modified by the use of chemotherapy or steroids. In the past few years, encouraging results have been obtained when using it as a biomarker in children with cancer, particularly with neutropenia and fever.
, a specificity of 76
, a predictive value of 93
and a negative predictive value of 45
to diagnose sepsis. The procalcitonin values were not modified by the use of chemotherapy or steroids. In the past few years, encouraging results have been obtained when using it as a biomarker in children with cancer, particularly with neutropenia and fever.
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