A New Insight into Fatty Acid Binding Protein 4 Mechanisms and Therapeutic Implications in Obesity-Associated Diseases: A Mini Review.

Fatty acid binding proteins (FABPs), such as FABP4 (aP2, A-FABP), are essential for cellular lipid regulation, membrane-protein interactions, and the modulation of metabolic and inflammatory pathways. FABP4, primarily expressed in adipocytes, monocytes, and macrophages, is integrated into signaling networks that influence immune responses and insulin activity. It has been linked to obesity, inflammation, lipid metabolism, insulin resistance, diabetes, cardiovascular disease, and cancer. Inhibition of FABP4 is emerging as a promising strategy for treating obesity-related conditions, particularly insulin resistance and diabetes. Elevated FABP4 levels in individuals with a BMI above 30 underscore its association with obesity. Furthermore, FABP4 levels are higher not only in the tissues but also in the blood, promoting the onset and development of various cancers. Understanding its broader role reveals involvement in the mechanisms underlying metabolic syndrome, contributing to various metabolic and inflammatory responses. While blocking FABP4 offers an alternative therapeutic approach, a comprehensive understanding of potential side effects is crucial before clinical use. This review aims to provide concise insights into FABP4, elucidating its mechanisms and potential therapeutic applications in obesity and associated disorders, contributing to innovative interventions against metabolic syndrome and obesity.

The role of intermittent fasting and the ketogenic diet in cancer disease: can they replace the Mediterranean diet?

The prevalence of cancer is rising globally, and it is the second leading cause of death. Nutrition has an important influence on the risk of developing cancer. Moreover, changes in the gut microbiota are connected to the risk of developing cancer and are critical for sustaining immunity. Various studies have shown that intermittent fasting, ketogenic diet, and the Mediterranean diet are effective therapies in changing the intestinal microbiota, the prevention of cancer, and the improvement of tolerance to treatment in cancer patients. Although there is not enough evidence to show that the ketogenic diet is effective in changing the intestinal microbiota in a manner that could prevent cancer, intermittent fasting and the Mediterranean diet could positively affect composition of intestinal microbiota against cancer. In addition, the ketogenic diet, intermittent fasting, and the Mediterranean diet have the potential to stimulate anticarcinogenic pathways, and they might increase cancer patients' quality of life according to scientific evidence. In this review, we represent and argue recent scientific data on relationship between intermittent fasting, the ketogenic diet, and the Mediterranean diet, intestinal microbiota, cancer prevention and cancer treatment.

Comparison of daily bisphenol A intake based on dietary and urinary levels in breastfeeding women.

Bisphenol A (BPA) is an artificial chemical, and one of the significant external routes of daily BPA exposure is diet. Dietary BPA exposure can be calculated by urinary BPA concentration and dietary recall data. This cross-sectional study investigates exclusively breastfeeding women's BPA exposure by urinary total BPA concentration and nutritional records, including the 24 h Dietary Recall (HDR) and Food Frequency Questionnaire (FFQ). In this study, we included exclusively breastfeeding, healthy women volunteers (n = 80; 18-40 years), collected spot-morning urine samples and conducted a comprehensive face-to-face survey. Moreover, the women's urine BPA concentration was adjusted according to their urine creatinine concentrations. We assessed dietary BPA intake with the 24HDR and FFQ. Estimated daily BPA exposure according to urinary output volume and urinary creatinine concentration median values were 0.0507 and 0.06 µg/kg bw/day, respectively. Moreover, dietary BPA daily intake was found to be 0.17 and 0.95 µg/kg bw/day according to 24HDR data and FFQ data. The milk and dairy product group's and soft drinks group's contributions to the daily intake of BPA were 55.9 % and 25.92 %, respectively. The hazard ratio for BPA exposure was within limits according to references, including US EPA, Health Canada, and EFSA. This study indicates that BPA exposure, based on both total urinary BPA concentration and dietary recall data, was within the recommended daily intake level (4 µg/kg bw/day). However, further studies are required to understand the influence of seasonal, multicentre, and socioeconomic differences on BPA exposure.

Bisphenol A Exposure in Exclusively Breastfed Infants and Lactating Women: An Observational Cross-sectional Study

Objective: Bisphenol A (BPA) is a known endocrine disruptor and free BPA will interact with estrogen. BPA is also fat soluble and will therefore contaminate breast milk. The European Food Safety Authority has set a limit for temporary tolerable daily intake of 4 µg/kg body weight/day in breastfeeding infants. The aim of this study was to measure human milk BPA concentrations in Turkish women and thus exclusively breastfed infants' exposure to BPA. Methods: Healthy, postnatal, exclusively breastfeeding women were recruited and breast milk samples were collected. Free BPA concentration was analyzed in the milk samples using competitive enzyme-linked immunosorbent assay. Participants' demographic characteristics and nutritional habits were investigated through face-to-face interviews using a detailed questionnaire. Results: Eighty women participated. Median milk free BPA level was 0.63 µg/L. There was no statistically significant association between maternal body mass index, birth type, parity, infant birth week, infant birth weight, and human milk BPA concentration. Nevertheless, there was a significant association between human milk BPA level and consumption of fast-food and carbonated drinks (p=0.022 and p=0.018, respectively). Exclusively breastfed infants' mean BPA exposure was 0.0099±0.0079 µg/kg bw/day. There was a moderate negative significant correlation between infant BPA exposure and infant current body weight (r=0.327, p=0.003). Conclusion: BPA exposure in exclusively breastfed infants was within accepted limits and the current dietary exposure level of infants in this cohort was safe.