Survey of acne-related post-inflammatory hyperpigmentation in the Middle East.

Aim: Acne vulgaris is a common inflammatory skin disease in the Middle East, similar to other regions of the world. In the Middle East, there are a relatively large proportion of patients with darker pigmentation (Fitzgerald skin types III-VI) who are prone to developing post-inflammatory hyperpigmentation (PIH) as a sequela of acne. Data are sparse on the frequency and characteristics of PIH throughout the world. What information is available indicates that pigmentation problems can be very bothersome for patients and are often quite long-lasting. Thus, it is important for clinicians to be aware of the scope of the problem of acne-associated PIH as well as potential treatment options. Methods: Prospective non-interventional study of acne patients consulting dermatologists (n = 262) in the Middle East. Results: PIH was present in 87.2% of subjects. The majority of subjects (52.6%) reported that PIH had been present for one year or longer. Of note, 69.0% of subjects reported excoriating their acne lesions, suggesting that this may be a key modifiable risk factor for clinicians to stress during patient education efforts. Conclusions: PIH was bothersome for patients, with half of subjects indicating that PIH was more bothersome than acne. In addition to our study results, we present here a brief overview of PIH and its treatment.

Managing acne in the Middle East: consensus recommendations.

Acne has been estimated to affect the majority of people at some point in their life and is common in Middle Eastern countries. While acne is frequently perceived to be a self-limited disease of adolescence, there is an increasing population of adults with acne. Information about the management of acne in the Middle East is somewhat sparse; however, several studies have recently been conducted and will be discussed in this supplement.

Incidence of Herpes (Pemphigoid) Gestationis inRiyadh Armed Forces Hospital Programme.

Full text is available as a scanned copy of the original print version.

Analysis of the lymphocytic infiltrate in a case of vitiligo.

We report a case of vitiligo notable for a degree and pattern of lymphocytic inflammation. Hypopigmentation and subsequent depigmentation developed in a 65-year-old man. Initial skin biopsy specimen from the border of a patch of hypopigmentation revealed a moderately dense perivascular and interstitial infiltrate of lymphocytes with exocytosis into epidermis and follicular epithelium. The pattern of the infiltrate suggested the diagnosis of cutaneous T-cell lymphoma or connective-tissue disease. Immunophenotypic analysis revealed a mature T-cell population with retention of pan-T-cell markers. Analysis of the T-cell receptor genome did not identify a rearranged clone. Six months later, the clinical and histologic findings were typical in a noninflamed lesion of vitiligo.

Dyskeratosis congenita in a female.

We report a 9-year-old Saudi girl with dyskeratosis congenita. In addition to the known manifestations of this disease, she also had the additional features of tufts of hairs on the limbs, and an early onset of keratinized basal cell papillomas on her trunk.

Autosomal recessive epidermolysis bullosa simplex. A case report.

We report a male child with autosomal recessive epidermolysis bullosa simplex presenting at birth. The patient subsequently developed cutaneous atrophy, nail dystrophy, milia and alopecia. He had growth retardation and anaemia, but there were no other associated abnormalities. Electron microscopy showed epidermolytic cleavage. The family history indicated an autosomal recessive mode of inheritance.

Cutaneous granuloma with ataxia telangiectasia--a case report and review of literature.

A patient is reported who had ataxia telangiectasia with multiple cutaneous lesions mainly on the limbs, which showed atrophy and scarring. Histopathology of these skin lesions showed tuberculoid granulomas without frank collagen necrobiosis in the dermis. Chromosomal analysis revealed a translocation between 7 and 14 as well as deletion of chromosomes 4 and 6.

Successful treatment of Sweet's syndrome with doxycycline.

Two patients with Sweet's syndrome are described, both of whom were treated with doxycycline 200 mg daily, and responded well to therapy. Doxycycline appears to be an effective alternative to corticosteroids for the treatment of Sweet's syndrome.

Etretinate in the treatment of ulcerative lichen planus.

Ulcerative lichen planus (ULP) is a rare variant of lichen planus. It is resistant to all therapeutic modalities, and most of the patients with this disorder described in the literature have been successfully treated only by surgical skin grafting. We report a case with ULP successfully treated with etretinate.

Subcorneal pustular dermatosis and IgA myeloma.

A case of subcorneal pustular dermatosis (SCPD), as a presenting feature in a patient with multiple myeloma, is described. This is the seventh case report of this association and the first from the Middle East. Five of these cases, including the present report, have been of the IgA paraprotein type, IgA intraepidermal deposits have been described in a few patients with SCPD associated with IgA paraproteinaemias but have not been detected in our patient.

White fibrous papulosis of the neck.

We report two middle-aged women who presented with multiple, discrete, non-follicular, oval, pale, asymptomatic lesions on the neck. Clinical and histopathological features were compatible with the entity of white fibrous papulosis of the neck.