RESUMEN
The title compound, C10H8BrN3OS2, a brominated di-thio-carbazate imine deriv-ative, was obtained from the condensation reaction of S-methyl-dithio-carbazate (SMDTC) and 5-bromo-isatin. The essentially planar mol-ecule exhibits a Z configuration, with the di-thio-carbazate and 5-bromo-isatin fragments located on the same sides of the C=N azomethine bond, which allows for the formation of an intra-molecular N-Hâ¯Ob (b = bromo-isatin) hydrogen bond generating an S(6) ring motif. In the crystal, adjacent mol-ecules are linked by pairs of N-Hâ¯O hydrogen bonds, forming dimers characterized by an R 2 2(8) loop motif. In the extended structure, mol-ecules are linked into a three-dimensional network by C-Hâ¯S and C-Hâ¯Br hydrogen bonds, C-Brâ¯S halogen bonds and aromatic π-π stacking.
RESUMEN
The title compound, C16H12FN3OS, a fluorinated di-thio-carbazate imine derivative, was synthesized by the one-pot, multi-component condensation reaction of hydrazine hydrate, carbon di-sulfide, 4-fluoro-benzyl chloride and isatin. The compound demonstrates near-planarity across much of the mol-ecule in the solid state and a Z configuration for the azomethine C=N bond. The Z form is further stabilized by the presence of an intra-molecular N-Hâ¯O hydrogen bond. In the extended structure, mol-ecules are linked into dimers by N-Hâ¯O hydrogen bonds and further connected into chains along either [20] or [100] by weak C-Hâ¯S and C-Hâ¯F hydrogen bonds, which further link into corrugated sheets and in combination form the overall three-dimensional network.
RESUMEN
The title compound, C17H15N3OS2 was obtained from the condensation reaction of S-benzyl-dithio-carbazate and 5-methyl-isatin. In the solid-state, the mol-ecule adopts a Z configuration with the 5-methyl-isatin and di-thio-carbazate groups located on the same side of the C=N bond, involving an intra-molecular N-Hâ¯O hydrogen bond.
RESUMEN
The title compound, C6H8N2O4, a new derivative of isoxazole, has been synthesized and structurally characterized. The crystal structure shows the mol-ecule to be almost planar (r.m.s. deviation for the non-hydrogen atoms = 0.029â Å), this conformation being supported by an intra-molecular N-Hâ¯O hydrogen bond. In the extended structure, the mol-ecules are linked by N-Hâ¯O hydrogen bonds into chains propagating along [010].
RESUMEN
A new isoxazole-based iodo-noium salt, C13H13INO5 +·C2F3O2 -, has been synthesized and structurally characterized. In the crystal, ions are linked by short Iâ¯O contacts to form a neutral tetra-ion aggregate. These combine with C-Hâ¯F and C-Hâ¯O inter-actions to form double-layered two-dimensional sheets in the (001) plane.
RESUMEN
The asymmetric unit of the title compound, C9H15NO4, consists of a functionalized pyrrolidine ring having an envelope conformation, synthesized as an ethyl ester. The mol-ecule has three chiral centres and crystallized as a racemic mixture. In the crystal, mol-ecules are linked by pairwise O-Hâ¯O bonds, generating dimers with twofold rotational symmetry.
RESUMEN
Halogenated analogues of the neurotoxic alkaloid muscimol were prepared with fluorine, iodine or trifluoromethyl at the 4 position of the isoxazole ring system. These compounds were investigated as agonists for GABAA receptors. Only the C-4 fluorine-containing analogue proved to be an active compound in these assays. The fluoro analogue was less active than muscimol, however it showed differential activity between synaptic (α1 ß2 γ2 ) and extrasynaptic (α4 ß2 γ) GABAA receptors, having a similar potency to the neurotransmitter GABA for the extrasynaptic (α4 ß2 γ) receptor.