Assessing the utility of osteoporosis self-assessment tool for Asians in patients undergoing hip surgery.

Objectives: Diagnosis and treatment of osteoporosis are instrumental in obtaining good outcomes of hip surgery. Measuring bone mineral density (BMD) using dual-energy X-ray absorptiometry (DXA) is the gold standard for diagnosing osteoporosis. However, due to limited access to DXA, there is a need for a screening tool to identify patients at a higher risk of osteoporosis. We analyzed the potential utility of the Osteoporosis Self-assessment Tool for Asians (OSTA) as a screening tool for osteoporosis. Methods: A total of 1378 female patients who underwent hip surgery at 8 institutions were analyzed. For each patient, the BMD of the proximal femoral region was measured by DXA (DXA-BMD), and the correlation with OSTA score (as a continuous variable) was assessed. Receiver operating characteristic (ROC) curve analysis was performed to assess the ability of OSTA score to predict osteoporosis. Lastly, the OSTA score was truncated to yield an integer (OSTA index) to clarify the percentage of patients with osteoporosis for each index. Results: DXA-BMD showed a strong correlation with OSTA (r = 0.683; P < 0.001). On ROC curve analysis, the optimal OSTA score cut-off value of -5.4 was associated with 73.8% sensitivity and 80.9% specificity for diagnosis of osteoporosis (area under the curve: 0.842). A decrease in the OSTA index by 1 unit was associated with a 7.3% increase in the probability of osteoporosis. Conclusions: OSTA is a potentially useful tool for screening osteoporosis in patients undergoing hip surgery. Our findings may help identify high-risk patients who require further investigation using DXA.

Asymptomatic Deep Venous Thrombosis After Elective Hip Surgery Could Be Allowed to Remain in Place Without Thromboprophylaxis After a Minimum 2-Year Follow-Up.

BACKGROUND: It is not clear how to treat asymptomatic deep venous thromboses (DVTs) following elective hip arthroplasty because the natural course of DVTs is unclear. It is therefore valuable to understand the natural course of DVTs and their relation to thromboprophylactic methods. METHODS: We followed 742 consecutive patients who underwent elective hip arthroplasty followed by mechanical or chemical prophylaxis of a DVT. All patients underwent preoperative and postoperative duplex ultrasonography of both limbs. Patients who developed postoperative DVT in the popliteal or calf vein were followed without thromboprophylaxis. DVT-positive patients were prospectively followed up with duplex ultrasonography at 3, 6, 12, and 24 months postoperatively. RESULTS: Incidences of preoperative and postoperative DVTs were 3.9% and 33.0%, respectively. Nonfatal pulmonary embolism (PE) occurred in 1 patient after negative echography. All DVTs that developed in the calf vein postoperatively and without anticoagulation remained benign, and 93% of the DVTs ultimately disappeared. CONCLUSION: These results confirmed that the natural course of asymptomatic distal DVTs is benign, with no risk of leading to PE. Thus, distal DVTs could be allowed to remain untreated without chemical prophylaxis to prevent PE in Asian populations.

Transitional changes in the incidence of hip osteonecrosis among renal transplant recipients.

BACKGROUND: Immunosuppressive therapy for renal allograft recipients has changed substantially since the introduction of the anti-CD25 monoclonal antibody, basiliximab. We hypothesized that recent improvements in immunosuppressive treatment may reduce the incidence of osteonecrosis of the femoral head (ONFH). This study aimed to investigate transitional changes in the incidence of OFNH among renal transplant recipients by MRI. METHODS: Participants comprised 110 patients who had undergone renal transplantation from 2003 to 2012, during which time basiliximab was in regular use at our institute (Recent group), and 232 patients who had undergone RT between 1986 and 2003 (Past group). We compared ONFH incidence between the two groups and evaluated risk factors for ONFH, including immunosuppressants (calcineurin inhibitors, basiliximab, and/or steroids) and postoperative renal function. RESULTS: Incidence of ONFH was lower in the Recent group (0%) than in the Past group (3.4%; p = 0.043). In the Recent group, age was greater, ABO/human leukocyte antigen incompatibility was worse, while steroid dose was decreased and post-transplant renal function was improved. Cumulative methylprednisolone dose at postoperative week 2 and delayed graft function were identified as risk factors for ONFH. CONCLUSION: Risk of ONFH after renal transplantation has fallen with the advent of regular use of basiliximab, although this agent does not appear to be a factor directly associated with the incidence of ONFH. STUDY DESIGN: Clinical prognostic study (Level III case control study).

Differences in activities of daily living after hip arthroplasty among hip resurfacing, anterolateral THA, and posterolateral THA: a propensity score matched analysis.

The aim was to elucidate the differences in activities of daily living (ADL) after hip arthroplasty among hip resurfacing (HRA), anterolateral total hip arthroplasty (AL-THA), and posterolateral THA (PL-THA) patients after age, sex, body mass index, bilateral/unilateral hip arthroplasty, and postoperative duration were matched using propensity scores. A total of 673 hips from 540 consecutive patients who underwent hip arthroplasty were included. A self-completed questionnaire on preoperative and postoperative ADLs was administered during postsurgical visits at least ≥ 4 years postoperatively. Between HRA and PL-THA patients, the numbers of patients who performed heels-down squatting was significantly more in HRA than in PL-THA. Between AL-THA and PL-THA patients, there were significant differences in postoperative ADLs including bathing in a bathtub, riding on a train/bus, cutting toenails, bowing while straight sitting, heels-up/down squatting, riding on a bicycle, driving a car, and domestic travel. There were no significant differences in postoperative ADLs between ≥ 36 mm head and ≤ 32 mm head PL-THA patients, and between AL-THA and HRA patients. This propensity score matched study indicated that AL-THA and HRA patients were more active postoperatively than PL-THA patients.

Characteristics of bone turnover markers in rapidly destructive coxopathy.

The purpose of this study was to clarify bone turnover marker levels in rapidly destructive coxopathy (RDC). Twenty patients with RDC (mean age, 72 ± 11 years; 3 men, 17 postmenopausal women), 111 with osteoarthritis (OA) (age, 60 ± 10 years; 15 men, 13 premenopausal women, 83 postmenopausal women), and 18 with osteonecrosis of femoral head (ON) (55 ± 14 years; 11 men, 3 premenopausal women, 4 postmenopausal women), and 100 patients with femoral neck fracture (FNF) (81 ± 10 years; 27 men, 73 postmenopausal women) were included. Serum tartrate-resistant acid phosphatase 5b (TRACP-5b), bone alkaline phosphatase (BAP), matrix metalloproteinase-3 (MMP-3) levels, and bone mineral density (BMD) of proximal femur and lumbar spine were investigated. TRACP-5b levels were significantly higher in RDC than in OA and ON, whereas BAP levels were higher in RDC than in OA (P < 0.05). MMP-3 levels were higher in RDC and ON than in OA (P < 0.05). TRACP-5b were higher in RDC than OA (P < 0.05) and FNF (P < 0.05) in performing propensity score matching; there were no differences in BMD between RDC and OA. TRACP-5b showed the largest area under the curve (AUC, 0.82) according to receiver operating characteristic (ROC) curve analysis for diagnosing RDC against OA and ON. AUCs of BAP and MMP-3 were 0.78 and 0.74. The respective sensitivities and specificities were 70.0 % and 85.3 % for TRACP-5b (cutoff, 623 mU/dl), 95.0 % and 57.1 % for BAP (13.8 U/l), and 70.0 % and 76.4 % for MMP-3 (52.7 ng/ml). The lack of differences in BMD suggested that high bone turnover marker levels may reflect osteoclast cell activation in RDC hips. Serum TRACP-5b and BAP could be RDC markers.

Difference in Stem Alignment Between the Direct Anterior Approach and the Posterolateral Approach in Total Hip Arthroplasty.

The purpose of this study was to investigate the effects of different surgical approaches, the posterolateral approach (PLA) and the direct anterior approach (DAA), on postoperative femoral anteversion and stem coronal and sagittal alignment in total hip arthroplasty (THA), and to identify the factors related to postoperative femoral anteversion and stem alignment. A total of 209 hips of 181 patients were evaluated. THA was performed through the PLA in 80 hips and through the DAA in 129 hips. Femoral anteversion and stem alignment were measured on postoperative computed tomography images. The factor related to postoperative anteversion change was preoperative femoral anteversion, and the surgical approaches did not affect the postoperative anteversion change, while surgical approach did have an effect on stem sagittal alignment.

Jogging after total hip arthroplasty.

BACKGROUND: Jogging has been classified as a high-impact sport, and jogging after total hip arthroplasty (THA) has not been well documented. PURPOSE: To investigate the participation rate for postoperative jogging as well as jogging parameters and the influence of jogging on implant stability and bearing wear. STUDY DESIGN: Case-control study; Level of evidence, 3. METHODS: Included in this study were 804 hips in 608 patients (85 men, 523 women) who underwent THA between 2005 and 2011 with follow-up longer than 1 year. The mean patient age was 62 years (range, 26-98 years), and mean follow-up duration was 4.8 years (range, 2.3-7.8 years). Hip resurfacing arthroplasty (HRA) was performed in 81 patients and conventional THA in 527 patients. During routine postsurgical visits, patients were given a questionnaire concerning preoperative and postoperative jogging routines. For joggers, frequency, distance, duration, and velocity of jogging were recorded. Patients who did not jog postoperatively were asked to provide reasons for not jogging. Radiographs concerning implant migration and polyethylene wear were evaluated with specialized software, and serum cobalt and chromium ion concentrations were investigated for patients with metal-on-metal articulation. RESULTS: A total of 33 patients (5.4%) performed jogging preoperatively, and 23 patients (3.8%) performed jogging postoperatively. Of the 23 who jogged postoperatively, conventional THA was performed in 13 patients and HRA in 10 patients. Postoperatively, joggers trained a mean of 4 times (range, 1-7 times) per week, covering a mean distance of 3.6 km (range, 0.5-15 km) in a mean time of 29 minutes (range, 5-90 minutes) per session and at a mean speed of 7.7 km/h (range, 3-18 km/h). No patient complained of pain or showed serum cobalt and chromium ion elevation greater than 7 ppb. No hip showed loosening, abnormal component migration, or excessive wear at a mean 5-year follow-up. There were 74 postoperative non-joggers with an interest in jogging. The reasons given for avoiding jogging included anxiety (45 patients; 61%); impossible because of several reasons, including pain, decreased range of motion, and muscle weakness (18 patients; 24%); and lumbar or knee pain (11 patients; 15%). Multivariate analysis revealed that male sex and a history of preoperative jogging demonstrated significant relationships with postoperative jogging. CONCLUSION: A total of 3.8% of THA patients participated in postoperative jogging. Short-term postoperative follow-up did not identify any negative influence of jogging on implant survival.

Synovial joint fluid cytokine levels in hip disease.

OBJECTIVE: The purpose of this study was to evaluate cytokine level characteristics in the hip joint fluid, including rapidly destructive coxopathy (RDC), OA, osteonecrosis (ON) of the femoral head and RA. METHODS: Thirty-three hips with RDC, 57 with OA, 36 with ON and 10 with RA were included in the study. OA hips were divided into two groups: 20 hips with early OA without joint space narrowing and 37 hips with terminal OA. ON hips were divided into three groups: 13 hips with <3 mm collapse, 14 hips with >3 mm collapse and 9 hips with terminal ON. Joint fluid was collected during surgery. Cytokine levels including IL-1ß, IL-6, IL-8 and TNF-α were measured using homogeneous time-resolved fluorescence. RESULTS: All measured cytokine levels in RDC were significantly higher than those in OA (P < 0.05). Terminal OA showed higher cytokine levels than those in early OA (P < 0.05). IL-6 and TNF-α levels in the ON group with >3 mm collapse were higher than those found in the ON group with <3 mm collapse. In comparing cytokine levels between RDC, terminal OA, RA and terminal ON, RDC showed significantly higher IL-8 levels than terminal OA and RA (P < 0.05). CONCLUSION: IL-8 levels in RDC were higher than in the other hip diseases. The IL-8 level may reflect the aggressiveness of joint destruction in RDC, and IL-6 and TNF-α levels may also reflect ongoing destruction in OA and ON.

Is the transverse acetabular ligament a reliable cup orientation guide?

BACKGROUND AND PURPOSE: It is controversial whether the transverse acetabular ligament (TAL) is a reliable guide for determining the cup orientation during total hip arthroplasty (THA). We investigated the variations in TAL anatomy and the TAL-guided cup orientation. METHODS: 80 hips with osteoarthritis secondary to hip dysplasia (OA) and 80 hips with osteonecrosis of the femoral head (ON) were examined. We compared the anatomical anteversion of TAL and the TAL-guided cup orientation in relation to both disease and gender using 3D reconstruction of computed tomography (CT) images. RESULTS: Mean TAL anteversion was 11° (SD 10, range -12 to 35). The OA group (least-square mean 16°, 95% confidence interval (CI): 14-18) had larger anteversion than the ON group (least-square mean 6.2°, CI: 3.8 - 7.5). Females (least-square mean 20°, CI: 17-23) had larger anteversion than males (least-square mean 7.0°, CI: 4.6-9.3) in the OA group, while there were no differences between the sexes in the ON group. When TAL was used for anteversion guidance with the radiographic cup inclination fixed at 40°, 39% of OA hips and 9% of ON hips had more than 10° variance from the target anteversion, which was 15°. INTERPRETATION: In ON hips, TAL is a good guide for determining cup orientation during THA, although it is not a reliable guide in hips with OA secondary to dysplasia. This is because TAL orientation has large individual variation and is influenced by disease and gender.