[Characteristics of the autonomic nervous system in patients with liver cirrhosis].

Investigation of autonomic nervous system state was realized in 98 cirrhotic patients. Learned correlating connections between indexes of heart rhythm variability and difficulty of liver cirrhosis according to Child-Pugh let us elaborate criteria of difficulty stage of vegetative disorders and form a computerized program "Hepatovega".

[New possibilities of Doppler flowmetric ultrasound diagnosis of portal hypertension complicated with varicose veins of the esophagus and bleeding prediction].

Liver cirrhosis as a stage in chronic diffuse liver diseases development manifests itself in structural remodeling of parenchyma and appearance of the main syndrome--portal hypertension. In turn it leads to hemorrhage in 54,3% with death rate of 30-50%. In the article research of hemodynamics in abdominal vessels by the means of modified sonographic Doppler flowmetry and prognosis of high risk esophageal varices are described. On the basis of statistical dependency between degree of esophageal varices, cirrhotic gastropathy and results of modified protocol close correlation is shown, which allow to recommend them as alternative in non-invasive diagnosis of liver cirrhosis complications.

[The differential assessment of the state of lipid peroxidation and of the antioxidant system in patients in the late period after gastric resection]. / Dyferentsiiovana otsinka stanu perekysnoho okyslennia lipidiv ta antyoksydantnoï systemy u khvorykh u viddalenomu periodi pislia rezektsiï shlunka.

Studied after stomach resection for ulcer disease in 161 patients were lipid peroxidation (LPO), antioxidant system (AOS) and related parameters characterizing metabolism of carbon (Lactat), protein (piruvat) and fat (fat acids, lipoproteins), an indicator of the dystrophic change degree (acid phosphatase). Revealed in these patients was syndrome of peroxidation, which leads to disturbances of protein, carbon and fat metabolism, destruction of cell membranes. Increased, "normal", weakened LPO was identified in 67.7%, 9.94%, 22.36% of the patients respectively. In patients with an increased LPO statistically significant activation of AOS was established, lactate having increased more than twice, pyruvate remaining unchanged; the level of fat acids and lipoproteins almost doubled. In such a situation it is reasonable to use preparations which activate aerobic glycolysis, and antioxidants of a direct, mild degree, action. In group II patients with more prominent increase in the acid phosphatase activity preference should be given to membrane-stabilizing preparations. In patients with a decreased level of LPO considerable increase in lactate and acid phosphatase was noted. It is recommended that preparations promoting normalization of carbon and lipid metabolism, enhancement of redox processes in the respiratory chain should be included into complex therapy as should be stabilizers of membranes of cell organelles, with biogenic stimulators to follow.