[Mechanisms of aging and age-related homeodynamics of bio-elementome.]

This article presents a data science review and our own evaluation on bio-element mediated aging of the human body from the point of view of homeodynamics of bioelementome. The study of bio-element basis of aging is currently one of the actively developing fields in gerontology. During postnatal ontogenesis, the bio-elementome shows no signs of stability. Being extremely dependent on endogenous and exogenous circumstances, the levels of macro- and microelements can either remain within the normal range or undergo significant changes, especially with the body aging. These bio-element developments appear to be very important in terms of a large number of currently known molecular, subcellular, cellular, and tissue mechanisms of aging (oxidative stress, loss of proteostasis, excessive telomere attrition, epigenetic landscape alterations, apoptosis, altered intercellular communication, and many others). Better understanding of metabolic pathways of essential bio-elements (intake in the gastrointestinal tract; absorption, including due to interaction with specific transporting proteins; spread through the circulatory system and the entire body; inclusion in specialized macromolecules and participation in their composition in biochemical processes; excretion from the body), as well as realizing their role in the mechanisms of senile tissue and organ involution, and features of age-related homeodynamics can significantly improve existing knowledge on the biology of aging.

[Bioelement status of older age residents of Magadan.]

By choosing discriminant variables as concentrations of significant chemicals, this study identified types of mature people bioelement pictures. The inductively coupled plasma atomic emission spectrometry/mass spectrometry method was used to measure Ca, Cu, Fe, K, Mg, Mn, Na, P and Zn concentrations in hair samples of 237 residents of Magadan aged 36-94. By cluster and discriminant analysis the concentrations of Ca, Mg, Mn and Zn were reliably (p=0,001) set as classifying parameters, which made it possible to divide the examinees into three groups based on the following types of bioelement status: regional norm (81,97% of the surveyed subjects), excess (16,87%) and hyper excess (0,84%). The status of regional norm proved to be mostly common in all the studied ages, regardless of gender. We could see the incidence of this bioelement type is growing to the extreme old age being characteristic of the changing element status as normal bioelement ageing. The status of hyper excess was only exhibited by women at their second adulthood. The status of bioelement excess is more common in women who reduce the chance of developing this condition from 33,9 to 4,8% as they move from second adulthood to senile age.