RESUMEN
We evaluated parameters of apoptosis in the mucosa of the gastric antrum and body of indigenous and non-indigenous residents of Khakassia with duodenal ulcer disease associated with Helicobacter pylori infection. In the gastric antrum, apoptotic index was significantly increased in patients with ulcer disease in comparison with healthy individuals in both populations. The ratio of proliferation index to apoptotic index was lower in patients with ulcer disease in comparison with healthy individuals in both populations. Similar, but less pronounced processes were recorded in the body of the stomach. Significant changes in the parameters of proliferation and apoptosis were noted in the gastric antrum and body of the stomach in both populations, but they were more pronounced in Caucasians in comparison with Khakasses.
Asunto(s)
Apoptosis/fisiología , Proliferación Celular/fisiología , Úlcera Duodenal/microbiología , Células Epiteliales/fisiología , Mucosa Gástrica/citología , Helicobacter pylori , Adulto , Úlcera Duodenal/patología , Endoscopía del Sistema Digestivo , Femenino , Humanos , Inmunohistoquímica , Masculino , Grupos de Población , Siberia , Estadísticas no ParamétricasRESUMEN
AIM: To investigate association of polymorphisms of IL-1 genes and antagonist of IL-2 receptor (IL1Ra). MATERIAL AND METHODS: Patients with chronic gastritis and ulcer were examined using the method of restriction analysis. RESULTS: It was found that CCILbeta and R4/R4IL1Ra are most prevalent allel variants in khakas population. CONCLUSION: It is expedient to define population risk and protective genotypes of development of ulcer associated with Helicobacter pylori in khakases.
