Analysis Of Serum Iron And Heamoglobin Level In Patients With Oral Submucous Fibrosis.

BACKGROUND: OSMF is chronic underlying disease. The disease is well recognized and had an importance due to high malignant transformation rate. Multiple etiological factors are found responsible in the pathogenesis of the disease course. The effect of areca-nut is mainly causing trismus of the oral cavity. This may compromise the food intake of the patients who are facing this precancerous disease. METHODS: Total one hundred and 28 patients were selected and equally distributed into two groups. It is an observational, cross- sectional study. Sixty four patient with OSMF were selected on the basis of fibrous band formation and mouth opening. The etiological factors such as chewing habit had been denoted in forms. The heamoglobin and iron levels were analyzed from laboratory using automated machines used for blood analysis. RESULTS: The OSMF group showed insignificant variation when the two groups were compared. Whereas the sub-groups of OSMF are showing moderately significant correlation for the serum iron and heamoglobin levels. The outcome of the present study emphases on the assessment of heamoglobin and serum iron for OSMF patients. The patients must be prescribed with the micronutrients therapy so that any deficiency which may contribute in the disease course can be intercepted at the beginning. Further the patients must be educated in term of quitting the chewing habit so that his/ her life not get compromised due to OSMF.

Chromosomal Breakage in Fanconi Anemia and Consanguineous Marriages: A Social Dilemma for Developing Countries.

Introduction A clear picture of the prevalence of Fanconi anemia is not known due to limited studies and research of the subject. This study will detect the frequency of positive chromosomal breakage in pediatric aplastic patients and provide the evidence-based guidelines which help in consideration of appropriate treatment and awareness to the society. Methods A total of 104 aplastic anemia patients were recruited of age <18 years whose samples were tested for chromosomal breakage with mitomycin C (MMC). History of consanguinity between parents were documented for all the patients referred to us. Result Out of 104 diagnosed aplastic anemia patients, 35 (33.7%) patients were found to be Fanconi positive. Mean age of all hypoplastic patients for aplastic anemia and Fanconi anemia was 10.7 ± 4.5 and 10.6 ± 3.5, respectively. Male preponderance was found to be higher (64, 61.5%) as compared to females (40, 38.5%) in aplastic patients. The male to female ratio was observed as 2.5:1 in Fanconi patients while 1.3:1 in non-Fanconi aplastic patients. Parental consanguinity was observed in 33 (94.2%) with Fanconi anemia. Conclusion Fanconi anemia accounts for significant number of patients with hypoplastic bone marrow, therefore consanguineous marriages should be avoided through mass education in Pakistan.