FRUCTOSAMINE VALUES IN MONITORING COMPENSATION AND EFFICACY OF DIABETES MELLITUS TREATMENT.

OBJECTIVE: Aim: The relevance of the study is determined by the objective of finding an optimal type of diagnostics of carbohydrate metabolism, that would assess the condition of a diabetic patient undergoing treatment. The purpose of the study is to create a model for monitoring the efficacy of diabetes mellitus treatment by determining the fructosamine levels. PATIENTS AND METHODS: Materials and Methods: The methods for investigating the highlighted issue are clinical examination and laboratory diagnosis of diabetic patients to measure the state of carbon metabolism using ion-exchange chromatography to determine glycated haemoglobin levels and an automatic colorimetric method to determine fructosamine levels. RESULTS: Results: The study presents certain values of fructosamine over the level of changes in the state of patients with diabetes mellitus, reflecting the progress from the treatment in the compensation of carbohydrate metabolism, which allows creating a model of diagnostic values of the fructosamine levels, according to which the efficacy of treatment of diabetes mellitus, the state of progress of the disease in its compensation or decompensation are determined at a qualitative level. CONCLUSION: Conclusions: This allows for the timely adaptive corrective therapeutic and preventive measures to be carried out by medical personnel, who, using values, will monitor the efficacy of treatment in each patient once every three weeks, as this will determine the influence of the type of conducted treatment or other factors aimed at compensating for pathogenetic and clinical manifestations of the disease, which makes the identified fructosamine criteria an important component in the treatment of diabetes mellitus, and indirectly allows to improve the life quality of this patient population, thus bringing a practical solution to the challenge facing the healthcare sector.

The Importance of Fructosamine for Monitoring the Compensation and Effectiveness of Diabetes Treatment.

BACKGROUND: The use of fructosamine to assess the glycemic control represents a new step in diagnostics, and it has been accompanied by the active scientific discussion in recent years. That is why the purpose of this work is to study the average level of fructosamine in apparently healthy individuals and individuals with diabetes mellitus (DM), as well as the possibility to use it when evaluating the effectiveness of inpatient treatment of patients with hyperglycemia on the seven to ten days of hospitalization. METHODS: This research work was carried out in Alma-Ata, Republic of Kazakhstan, based on the endocrinology department in the period from 2020 to 2022. The work consists of a retrospective analysis of previously examined patients and a prospective stage. The statistical evaluation was carried out with the calculation of reliability coefficient, confidence interval, and criteria for testing for normality. The level of fructosamine in healthy individuals in the corresponding region was analyzed in this article for the first time, and the correlation between this indicator and the level of glycated hemoglobin was found. RESULTS: The effectiveness of treatment of the Type 2 DM (according to the treatment protocol) has also been studied in stationary conditions for the seven to ten days, which makes it possible to judge the effectiveness of the prescribed therapy. CONCLUSIONS: These results will allow identifying the irrationality of the prescribed therapy at an early stage, which is especially important for the correct management of patients with this pathology, and minimizing the possible complications.