Delocalized Electric Field Enhancement through Near-Infrared Quasi-BIC Modes in a Hollow Cuboid Metasurface.

The two main problems of dielectric metasurfaces for sensing and spectroscopy based on electromagnetic field enhancement are that resonances are mainly localized inside the resonator volume and that experimental Q-factors are very limited. To address these issues, a novel dielectric metasurface supporting delocalized modes based on quasi-bound states in the continuum (quasi-BICs) is proposed and theoretically demonstrated. The metasurface comprises a periodic array of silicon hollow nanocuboids patterned on a glass substrate. The resonances stem from the excitation of symmetry-protected quasi-BIC modes, which are accessed by perturbing the arrangement of the nanocuboid holes. Thanks to the variation of the unit cell with a cluster of four hollow nanocuboids, polarization-insensitive, delocalized modes with ultra-high Q-factor are produced. In addition, the demonstrated electric field enhancements are very high (103-104). This work opens new research avenues in optical sensing and advanced spectroscopy, e.g., surface-enhanced Raman spectroscopy.

Advanced Light Source Technologies for Photodynamic Therapy of Skin Cancer Lesions.

Photodynamic therapy (PDT) is an increasingly popular dermatological treatment not only used for life-threatening skin conditions and other tumors but also for cosmetic purposes. PDT has negligible effects on underlying functional structures, enabling tissue regeneration feasibility. PDT uses a photosensitizer (PS) and visible light to create cytotoxic reactive oxygen species, which can damage cellular organelles and trigger cell death. The foundations of modern photodynamic therapy began in the late 19th and early 20th centuries, and in recent times, it has gained more attention due to the development of new sources and PSs. This review focuses on the latest advancements in light technology for PDT in treating skin cancer lesions. It discusses recent research and developments in light-emitting technologies, their potential benefits and drawbacks, and their implications for clinical practice. Finally, this review summarizes key findings and discusses their implications for the use of PDT in skin cancer treatment, highlighting the limitations of current approaches and providing insights into future research directions to improve both the efficacy and safety of PDT. This review aims to provide a comprehensive understanding of PDT for skin cancer treatment, covering various aspects ranging from the underlying mechanisms to the latest technological advancements in the field.

Polarisation-independent ultrafast laser selective etching processing in fused silica.

In fused silica, ultrafast laser assisted etching enables high chemical etching rates (>300 µm h-1) by setting a light polarisation linear and perpendicular to the beam writing direction. However, for many non-planar surfaces and 3D structures, dynamic polarisation control is difficult or not yet possible to implement. In this contribution, we identify a laser inscription regime in which high etching rates are accomplished independently of the light polarisation. In this regime (<15 pulses per µm), we measure etching rates ∼300 µm h-1 (4 hours in NaOH) including femtosecond-pulse energies corresponding to type II modifications. Few pulse inscriptions show a low degree of anisotropy as compared to higher number of pulses, thus enabling the polarisation insensitivity whose mechanisms are discussed. To demonstrate the capabilities of the processing, we fabricate curved and square-wave microchannels together with a complex 3D geometrical structure (stellated octahedron) containing an inter-plane arrangement with challenging angles (45°), which are difficult to achieve even employing dynamic polarisation control.

Design and Verification of Integrated Circuitry for Real-Time Frailty Monitoring.

In this study, a new wireless electronic circuitry to analyze weight distribution was designed and incorporated into a chair to gather data related to common human postures (sitting and standing up). These common actions have a significant impact on various motor capabilities, including gait parameters, fall risk, and information on sarcopenia. The quality of these actions lacks an absolute measurement, and currently, there is no qualitative and objective metric for it. To address this, the designed analyzer introduces variables like Smoothness and Percussion to provide more information and objectify measurements in the assessment of stand-up/sit-down actions. Both the analyzer and the proposed variables offer additional information that can objectify assessments depending on the clinical eye of the physicians.

Non-Contact Thermal and Acoustic Sensors with Embedded Artificial Intelligence for Point-of-Care Diagnostics.

This work involves exploring non-invasive sensor technologies for data collection and preprocessing, specifically focusing on novel thermal calibration methods and assessing low-cost infrared radiation sensors for facial temperature analysis. Additionally, it investigates innovative approaches to analyzing acoustic signals for quantifying coughing episodes. The research integrates diverse data capture technologies to analyze them collectively, considering their temporal evolution and physical attributes, aiming to extract statistically significant relationships among various variables for valuable insights. The study delineates two distinct aspects: cough detection employing a microphone and a neural network, and thermal sensors employing a calibration curve to refine their output values, reducing errors within a specified temperature range. Regarding control units, the initial implementation with an ESP32 transitioned to a Raspberry Pi model 3B+ due to neural network integration issues. A comprehensive testing is conducted for both fever and cough detection, ensuring robustness and accuracy in each scenario. The subsequent work involves practical experimentation and interoperability tests, validating the proof of concept for each system component. Furthermore, this work assesses the technical specifications of the prototype developed in the preceding tasks. Real-time testing is performed for each symptom to evaluate the system's effectiveness. This research contributes to the advancement of non-invasive sensor technologies, with implications for healthcare applications such as remote health monitoring and early disease detection.

Photonic Microfluidic Technologies for Phytoplankton Research.

Phytoplankton is a crucial component for the correct functioning of different ecosystems, climate regulation and carbon reduction. Being at least a quarter of the biomass of the world's vegetation, they produce approximately 50% of atmospheric O2 and remove nearly a third of the anthropogenic carbon released into the atmosphere through photosynthesis. In addition, they support directly or indirectly all the animals of the ocean and freshwater ecosystems, being the base of the food web. The importance of their measurement and identification has increased in the last years, becoming an essential consideration for marine management. The gold standard process used to identify and quantify phytoplankton is manual sample collection and microscopy-based identification, which is a tedious and time-consuming task and requires highly trained professionals. Microfluidic Lab-on-a-Chip technology represents a potential technical solution for environmental monitoring, for example, in situ quantifying toxic phytoplankton. Its main advantages are miniaturisation, portability, reduced reagent/sample consumption and cost reduction. In particular, photonic microfluidic chips that rely on optical sensing have emerged as powerful tools that can be used to identify and analyse phytoplankton with high specificity, sensitivity and throughput. In this review, we focus on recent advances in photonic microfluidic technologies for phytoplankton research. Different optical properties of phytoplankton, fabrication and sensing technologies will be reviewed. To conclude, current challenges and possible future directions will be discussed.

Enhanced refractometer for aqueous solutions based on perfluorinated polymer optical fibres.

The use of the new CYTOP (Cyclized Transparent Optical Polymer) fibres for the inscription of optical structures and the detection of different parameters has started to gain importance in the past decade. This work presents the design, simulation and manufacture of a CYTOP-based surrounding refractive index sensor for aqueous solutions, given its high sensitivity in the range 1.315 - 1.333 (at 1550 nm wavelength). The structure is based on a bent and polished fibre (in order to increase its sensitivity), the polished area being the surface on which a diffraction grating is inscribed with a femtosecond laser. The interaction of the field propagated by the fibre with the grating causes diffraction of certain orders towards the outside, depending, among other things, on the refractive index of the fluid. In addition to a maximum sensitivity of -208.8 nm/RIU and a remarkable insensitivity to temperature, it offers a spectral fingerprint of each sensed fluid.

Recent Advances in Biomedical Photonic Sensors: A Focus on Optical-Fibre-Based Sensing.

In this invited review, we provide an overview of the recent advances in biomedical photonic sensors within the last five years. This review is focused on works using optical-fibre technology, employing diverse optical fibres, sensing techniques, and configurations applied in several medical fields. We identified technical innovations and advancements with increased implementations of optical-fibre sensors, multiparameter sensors, and control systems in real applications. Examples of outstanding optical-fibre sensor performances for physical and biochemical parameters are covered, including diverse sensing strategies and fibre-optical probes for integration into medical instruments such as catheters, needles, or endoscopes.

Photodynamic Therapy: A Compendium of Latest Reviews.

Photodynamic therapy (PDT) is a promising therapy against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present a brief compendium of reviews of the last two decades classified under different topics, namely, overviews, reviews about specific cancers, and meta-analyses of photosensitisers, PDT mechanisms, dosimetry, and light sources. The key issues and main conclusions are summarized, including ways and means to improve therapy and outcomes. Due to the broad scope of this work and it being the first time that a compendium of the latest reviews has been performed for PDT, it may be of interest to a wide audience.

Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review.

Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some of the main beneficial features of PDT. Despite the great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, and complicated implementations in the clinic are some limiting factors hindering the extended use of PDT. To surpass actual technological paradigms, radically new sources, light-based devices, advanced photosensitisers, measurement devices, and innovative application strategies are under extensive investigation. The main aim of this review is to highlight the advantages/pitfalls, technical challenges and opportunities of PDT, with a focus on technologies for light activation of photosensitisers, such as light sources, delivery devices, and systems. In this vein, a broad overview of the current status of superficial, interstitial, and deep PDT modalities-and a critical review of light sources and their effects on the PDT process-are presented. Insight into the technical advancements and remaining challenges of optical sources and light devices is provided from a physical and bioengineering perspective.

Toroidal metasurface resonances in microwave waveguides.

We theoretically investigate the possibility to load microwave waveguides with dielectric particle arrays that emulate the properties of infinite, two-dimensional, all-dielectric metasurfaces. First, we study the scattering properties and the electric and magnetic multipole modes of dielectric cuboids and identify the conditions for the excitation of the so-called anapole state. Based on the obtained results, we design metasurfaces composed of a square lattice of dielectric cuboids, which exhibit strong toroidal resonances. Then, three standard microwave waveguide types, namely parallel-plate waveguides, rectangular waveguides, and microstrip lines, loaded with dielectric cuboids are designed, in such a way that they exhibit the same resonant features as the equivalent dielectric metasurface. The analysis shows that parallel-plate and rectangular waveguides can almost perfectly reproduce the metasurface properties at the resonant frequency. The main attributes of such resonances are also observed in the case of a standard impedance-matched microstrip line, which is loaded with only a small number of dielectric particles. The results demonstrate the potential for a novel paradigm in the design of "metasurface-loaded" microwave waveguides, either as functional elements in microwave circuitry, or as a platform for the experimental study of the properties of dielectric metasurfaces.

Anapole Modes in Hollow Nanocuboid Dielectric Metasurfaces for Refractometric Sensing.

This work proposes the use of the refractive index sensitivity of non-radiating anapole modes of high-refractive-index nanoparticles arranged in planar metasurfaces as a novel sensing principle. The spectral position of anapole modes excited in hollow silicon nanocuboids is first investigated as a function of the nanocuboid geometry. Then, nanostructured metasurfaces of periodic arrays of nanocuboids on a glass substrate are designed. The metasurface parameters are properly selected such that a resonance with ultrahigh Q-factor, above one million, is excited at the target infrared wavelength of 1.55 µm. The anapole-induced resonant wavelength depends on the refractive index of the analyte superstratum, exhibiting a sensitivity of up to 180 nm/RIU. Such values, combined with the ultrahigh Q-factor, allow for refractometric sensing with very low detection limits in a broad range of refractive indices. Besides the sensing applications, the proposed device can also open new venues in other research fields, such as non-linear optics, optical switches, and optical communications.

Infiltrated Photonic Crystal Fibers for Sensing Applications.

Photonic crystal fibers (PCFs) are a special class of optical fibers with a periodic arrangement of microstructured holes located in the fiber's cladding. Light confinement is achieved by means of either index-guiding, or the photonic bandgap effect in a low-index core. Ever since PCFs were first demonstrated in 1995, their special characteristics, such as potentially high birefringence, very small or high nonlinearity, low propagation losses, and controllable dispersion parameters, have rendered them unique for many applications, such as sensors, high-power pulse transmission, and biomedical studies. When the holes of PCFs are filled with solids, liquids or gases, unprecedented opportunities for applications emerge. These include, but are not limited in, supercontinuum generation, propulsion of atoms through a hollow fiber core, fiber-loaded Bose⁻Einstein condensates, as well as enhanced sensing and measurement devices. For this reason, infiltrated PCF have been the focus of intensive research in recent years. In this review, the fundamentals and fabrication of PCF infiltrated with different materials are discussed. In addition, potential applications of infiltrated PCF sensors are reviewed, identifying the challenges and limitations to scale up and commercialize this novel technology.

Tunable liquid crystal multifocal microlens array.

A novel liquid crystal microlens array with tunable multifocal capability, high optical power and fill-factor is proposed and experimentally demonstrated. A specific hole pattern design produces a multifocal array with only one voltage control. Three operations modes are possible, "Off", "Tunable Multifocal" and "Unifocal". The design is patterned in both substrates. Then, the substrates are arranged in symmetrical configuration. The result is a high optical power in comparison with typical hole patterned structures. Besides, it is proposed a hexagonal pattern that produces a high fill factor, specially indicated for some applications as Integral Imaging. The array has several useful characteristics for this type of application: tunability for the loss of resolution; multifocal for extended DOF; high fill factor for increase the number of views; and low power consumption for integration in portable devices. Moreover, the optical characteristics of the proposed device could bring new applications in other fields.

Low aberration and fast switching microlenses based on a novel liquid crystal mixture.

In this work, we present a novel kind of LC mixture (5005) for photonic applications, with emphasis on a LC microlens array. This mixture is a nematic composition of three different families of rod like liquid crystals. The key is that frequency dependence of parallel component of electric permittivity is different for each component, resulting in a strongly dependent on frequency dielectric anisotropy. The unique properties of this LC mixture are demonstrated to work in a frequency modulated LC microlens array. A hole patterned structure is used. Thanks to the special characteristics of this mixture, the microlenses are reconfigurable by low voltage signals with variable frequency. This is a first demonstration of a LC lens with tunable focal length by frequency in an analog way. The result of this type of control are microlenses with low aberrations and fast switching (the frequency switching is around 10 times faster than amplitude modulation). The tunability with frequency and the fast switching, makes this liquid crystal of special interest not only for microlenses but for all kind of optical phase modulators.

Selective Dielectric Metasurfaces Based on Directional Conditions of Silicon Nanopillars.

Dielectric metasurfaces based on high refractive index materials have been proposed recently. This type of structure has several advantages over their metallic counterparts. In this work, we demonstrate that dielectric metasurfaces can be theoretically designed satisfying Kerker's zero-forward condition. This is the first time that a dielectric metasurface based on this principle has been designed. A selective dielectric metasurface of silicon nanopillars is designed to work at 632.8 nm. This structure could work both as a dielectric mirror and a reject band filter. Furthermore, by scaling up the structure, it could be possible to manufacture a terahertz (THz) dielectric mirror.

Liquid crystal spherical microlens array with high fill factor and optical power.

A novel liquid crystal spherical microlens array with high optical power and almost 100% of fill-factor is proposed and experimentally demonstrated. The combination of a specific structure and electrical waveforms applied to the electrodes generates an array of spherical microlenses with square aperture. The manufacturing process is simple (patterned electrodes) and the microlenses are reconfigurable by low voltage signals (the electrodes are in contact with the LC layer). This device could be a key for the next generation of autostereoscopic devices based on Integral Imaging technique.

Liquid Crystal Microlenses for Autostereoscopic Displays.

Three-dimensional vision has acquired great importance in the audiovisual industry in the past ten years. Despite this, the first generation of autostereoscopic displays failed to generate enough consumer excitement. Some reasons are little 3D content and performance issues. For this reason, an exponential increase in three-dimensional vision research has occurred in the last few years. In this review, a study of the historical impact of the most important technologies has been performed. This study is carried out in terms of research manuscripts per year. The results reveal that research on spatial multiplexing technique is increasing considerably and today is the most studied. For this reason, the state of the art of this technique is presented. The use of microlenses seems to be the most successful method to obtain autostereoscopic vision. When they are fabricated with liquid crystal materials, extended capabilities are produced. Among the numerous techniques for manufacturing liquid crystal microlenses, this review covers the most viable designs for its use in autostereoscopic displays. For this reason, some of the most important topologies and their relation with autostereoscopic displays are presented. Finally, the challenges in some recent applications, such as portable devices, and the future of three-dimensional displays based on liquid crystal microlenses are outlined.

Electrical response of liquid crystal cells doped with multi-walled carbon nanotubes.

The inclusion of nanoparticles modifies a number of fundamental properties of many materials. Doping of nanoparticles in self-organized materials such as liquid crystals may be of interest for the reciprocal interaction between the matrix and the nanoparticles. Elongated nanoparticles and nanotubes can be aligned and reoriented by the liquid crystal, inducing noticeable changes in their optical and electrical properties. In this work, cells of liquid crystal doped with high aspect ratio multi-walled carbon nanotubes have been prepared, and their characteristic impedance has been studied at different frequencies and excitation voltages. The results demonstrate alterations in the anisotropic conductivity of the samples with the applied electric field, which can be followed by monitoring the impedance evolution with the excitation voltage. Results are consistent with a possible electric contact between the coated substrates of the LC cell caused by the reorientation of the nanotubes. The reversibility of the doped system upon removal of the electric field is quite low.