1.
Bioorg Med Chem Lett
; 14(5): 1221-7, 2004 Mar 08.
Artículo
en Inglés
| MEDLINE
| ID: mdl-14980670
RESUMEN
A variety of P4 motifs have been examined to increase the binding affinity and in vitro anticoagulant potency of our biphenyl 1-(2-naphthyl)-1H-pyrazole-5-carboxylamide-based fXa inhibitors. Highly potent 2-naphthyl-P1 fXa inhibitors (K(i)< or =2 nM) with improved in vitro anticoagulant activity (2xTG< or =1 microM) and respectable pharmacokinetic properties have been discovered.