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Nat Commun ; 13(1): 946, 2022 02 17.
Artículo en Inglés | MEDLINE | ID: mdl-35177642

RESUMEN

COVID-19 complications still present a huge burden on healthcare systems and warrant predictive risk models to triage patients and inform early intervention. Here, we profile 893 plasma proteins from 50 severe and 50 mild-moderate COVID-19 patients, and 50 healthy controls, and show that 375 proteins are differentially expressed in the plasma of severe COVID-19 patients. These differentially expressed plasma proteins are implicated in the pathogenesis of COVID-19 and present targets for candidate drugs to prevent or treat severe complications. Based on the plasma proteomics and clinical lab tests, we also report a 12-plasma protein signature and a model of seven routine clinical tests that validate in an independent cohort as early risk predictors of COVID-19 severity and patient survival. The risk predictors and candidate drugs described in our study can be used and developed for personalized management of SARS-CoV-2 infected patients.


Asunto(s)
Proteínas Sanguíneas/análisis , COVID-19/mortalidad , COVID-19/patología , Índice de Severidad de la Enfermedad , Adulto , Citocinas/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Pronóstico , Proteómica/métodos , SARS-CoV-2/efectos de los fármacos , Adulto Joven , Tratamiento Farmacológico de COVID-19
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