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J Pediatr Hematol Oncol ; 33(4): e154-5, 2011 May.
Artículo en Inglés | MEDLINE | ID: mdl-21423042

RESUMEN

We report a rare case of ovarian function recovery and pregnancy after hormone-replacement therapy (HRT) in the acute myeloblastic leukemia (AML) patient in third complete remission received hematopoietic stem cell transplantation (HSCT) with busulphan-based conditioning regimen. Successful engraftment of the donor cells and full donor's chimerism was achieved without the signs of leukemia. One year after HSCT the patient received a course of HRT as a treatment of hypergonadotropic hypogonadism. After 12 months of HRT the recovery of ovarian function was confirmed. Eight years after the HSCT spontaneous pregnancy occurred; heartbeat of the fetus was registered on week 7. Three weeks later a nonsevere vaginal bleeding occurred and the ultrasound examination showed a nondeveloping pregnancy. Genetic examination of the abortion material showed a full triploid genotype (69 XXX). To our knowledge this is a first case of ovarian function restoration and spontaneous pregnancy in a AML patient after multiple courses of high-dose chemotherapy and busulphan-based myeloablative conditioning for HSCT.


Asunto(s)
Busulfano/administración & dosificación , Trasplante de Células Madre Hematopoyéticas , Leucemia Mieloide Aguda/tratamiento farmacológico , Ovario/fisiología , Recuperación de la Función , Acondicionamiento Pretrasplante/métodos , Adolescente , Antineoplásicos/administración & dosificación , Antineoplásicos/efectos adversos , Busulfano/efectos adversos , Niño , Terapia Combinada , Femenino , Humanos , Hipogonadismo/tratamiento farmacológico , Agonistas Mieloablativos/administración & dosificación , Agonistas Mieloablativos/efectos adversos , Embarazo , Resultado del Embarazo , Acondicionamiento Pretrasplante/efectos adversos , Adulto Joven
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