RESUMEN
The synthesis of ß-(C3)-functionalized pyrroles is a challenging task and requires a multistep protocol. An operationally simple direct catalytic synthesis of ß-substituted pyrroles has been developed. This one-pot multicomponent method combined aqueous succinaldehyde as 1,4-dicarbonyl, primary amines, and isatins to access hydroxyl-oxindole ß-tethered pyrroles. Direct synthesis of the ß-substituted free NH-pyrrole is the central intensity of this work. DFT-calculations and preliminary mechanism investigation support the possible reaction pathway.
RESUMEN
In the title mol-ecule, C20H30O4, both cyclo-hexane rings adopt chair conformations. In the crystal, mol-ecules are connected by O-Hâ¯O hydrogen bonds forming chains along [100]. In addtion, an intra-molecular O-Hâ¯O hydrogen bond forms an S(5) ring.
RESUMEN
In the title mol-ecule, C20H19NO2, the naphthalene ring system subtends a dihedral angle of 82.50â (7)° with the benzene ring and an intra-molecular N-Hâ¯O hydrogen bond closes an S(6) ring. In the crystal, mol-ecules are linked by O-Hâ¯O hydrogen bonds, which generate C(8) chains propagating in the [010] direction. The crystal structure also features weak π-π inter-actions [centroid-centroid separation = 3.7246â (10)â Å].
RESUMEN
In the title mol-ecular complex, [Ni(C3H5OS2)2(C5H4BrN)2], the Ni(2+) cation is located on a centre of inversion and has a distorted octa-hedral N2S4 environment defined by two chelating xanthate ligands and two monodentate pyridine ligands. The C-S bond lengths of the thio-carboxyl-ate group are indicative of a delocalized bond and the O-Csp (2) bond is considerably shorter than the O-Csp (3) bond, consistent with a significant contribution of one resonance form of the xanthate anion that features a formal C=O+ unit and a negative charge on each of the S atoms. The packing of the mol-ecules is stabilized by C-Hâ¯S and C-Hâ¯π inter-actions. In addition, π-π inter-actions between the pyridine rings [centroid-to-centroid distance = 3.797â (3)â Å] are also present. In the crystal structure, mol-ecules are arranged in rows along [100], forming layers parallel to (010) and (001).
RESUMEN
In the title mol-ecule, C17H15ClN4S, the benzene rings form dihedral angles of 16.6â (1) and 77.2â (1)° with the triazole ring. The dihedral angle between the benzene rings is 86.6â (1)°. In the crystal, pairs of N-Hâ¯S hydrogen bonds form inversion dimers with graph-set notation R 2 (2)(8). Weak C-Hâ¯S hydrogen bonds link these dimers into layers parallel to (100). Weak intra-molecular C-Hâ¯S and C-Hâ¯N contacts are observed.
RESUMEN
In the title mol-ecule, C24H22N4O3, the plane of the oxa-diazole ring forms a dihedral angle of 32.41â (12)° with that of the phenyl ring and dihedral angles of 74.51â (10) and 56.38â (10)° with the planes of the benzene rings. In the crystal, pairs of N-Hâ¯N hydrogen bonds link molecules into inversion dimers featuring R 2 (2)(8) graph-set motifs.
RESUMEN
In the title mol-ecule, C10H12N4SO, the triazole ring forms a dihedral angle of 73.0â (5)° with the benzene ring. The meth-oxy group is approximtely coplanar with the benzene ring with a C C-O-Cmeth-yl torsion angle of 4.7â (3)°. In the crystal, N-Hâ¯S hydrogen bonds connect pairs of inversion-related mol-ecules, which are in turn connected by N-Hâ¯N hydrogen bonds into chains of rings along [010]. Weak C-Hâ¯O hydrogen bonds connect these chains into a two-dimensional network parallel to (-102).
RESUMEN
In the title compound, C32H26Cl2F2N2O2, the tetra-hydro-pyridine ring adopts a distorted boat conformation. The chlorophenyl rings are inclined to one another by 55.2â (1)°, while for the fluorophenyl rings the dihedral angle is 80.7â (1)°. The amino group and carbonyl O atom are involved in an intra-molecular N-Hâ¯O hydrogen bond. In the crystal, weak C-Hâ¯O, C-Hâ¯F and C-Hâ¯Cl inter-actions link the mol-ecules into a three-dimensional network.
RESUMEN
In the title mol-ecule, C31H24F4N2O2, the tetra-hydro-pyridine ring adopts a distorted boat conformation. An intra-molecular N-Hâ¯O hydrogen bond is formed by the amino group and ccarboxyl C=O atom. The crystal structure features weak C-Hâ¯F and C-Hâ¯O inter-actions.
RESUMEN
In the title mol-ecule, C34H32Cl2N2O2, the tetra-hydro-pyridine ring adopts a distorted boat conformation and both 4-chloro-phenyl substituents are in axial positions. An intra-molecular N-Hâ¯O hydrogen bond is formed by the amino group and carbonyl O atom. In the crystal, weak C-Hâ¯Cl inter-actions link the mol-ecules into chains along [010].
RESUMEN
In the title compound, C(32)H(28)F(2)N(2)O(2), the tetra-hydro-pyridine ring adopts a distorted boat conformation. The two fluoro-phenyl groups are attached to the tetra-hydro-pyridine ring in a trans orientation. The dihedral angle between the planes of the fluoro-substituted rings is 57.0â (1)°. The amino group and carbonyl O atom are involved in intra-molecular hydrogen bonding. In the crystal, weak C-Hâ¯O, C-Hâ¯F and C-Hâ¯π inter-actions link the mol-ecules into columns along [010].
RESUMEN
The asymmetric unit of the title compound, C(19)H(19)ClO(4), contains two independent mol-ecules. The dihedral angles between the benzene rings are 63.41â (8) and 61.41â (9)°. Adjacent mol-ecules of different types are inter-connected in pairs through π-π inter-actions between their central benzene rings [centroid-centroid separation = 3.801â (2)â Å, inter-planar spacing = 3.605â (2)â Å, centroid shift = 1.204â (2)â Å]. Finally, C-Hâ¯O hydrogen bonds link these dimers into bilayers parallel to (100).
RESUMEN
In the title mol-ecule, C(19)H(20)N(2)O(2), the cyclo-hexene ring adopts a sofa conformation, while the pyran ring adopts a flattened boat conformation. In the crystal, mol-ecules are linked by N-Hâ¯N and N-Hâ¯O hydrogen bonds, forming a two-dimensional network parallel to (010).
RESUMEN
The asymmetric unit of the title compound, C(14)H(16)ClNO, contains two independent mol-ecules, both with the cyclo-hexene ring in a sofa conformation. In the crystal, N-Hâ¯O hydrogen bonds link the mol-ecules related by translation along the a axis into two crystallographically independent chains. Weak C-Hâ¯π inter-actions are also observed.
RESUMEN
In the title compound, C(11)H(12)O(2), the dihedral angle between the benzene ring and the but-3-en-2-one group is 4.04â (5)°. The crystal packing features chains, parallel to [-101], composed of dimers connected by weak C-Hâ¯O inter-actions..
RESUMEN
In the title compound, C(14)H(10)O(2), the tricycle is not planar, being bent with a dihedral angle of 4.7â (1)° between the two benzene rings. In the crystal, π-π inter-actions between the six-membered rings of neighbouring mol-ecules [centroid-centroid distances = 3.580â (3) and 3.605â (3)â Å] form stacks propagating along [101].
RESUMEN
In the title mol-ecule, C(22)H(24)OSi, the Si-O-C angle is 139.79â (11)°, the O-C-C angles of the triphenyl-meth-oxy group are in the range 106.13â (13)-109.22â (14)° and the O-Si-C angles of the trimethyl-sil-yloxy group are in the range 103.08â (10)-113.53â (10)°. In the crystal, face-to-face π-π interactions are observed between the phenyl rings [centroid separation = 4.194â (1)â Å, interplanar spacing = 3.474â Å and centroid shift = 2.35â Å]. The three phenyl groups of the triphenyl-methyl substituent are mutually nearly perpendicular, with dihedral angles in the range 80.49â (8)-81.53â (8)°. There are only weak inter-molecular van der Waals inter-actions in the crystal.