RESUMEN
Neuroendocrine carcinoma of the breast is an extremely rare tumor. A standard treatment has yet to be established because only a few cases have been reported in literature. The authors report five cases observed from January 2007 to December 2014 and a review of literature. Four patients underwent quadrantectomy and in two cases axillary nodal dissection and only one to mastectomy with axillary nodal dissection. Tumor size was from T1 to T2 with N0 to N1, according TNM classification. Pathological specimens were stained with hematoxylin and eosin and an immunohistochemical panel of antibodies (Neuron-specific enolase, Chromogranin, Synaptophysin, Estrogen and Progesterone receptors, c-erb and Ki-67). All cases showed markers positivity to Neuron-specific enolase, Chromogranin, Synaptophysin and Estrogen and Progesterone receptors were found. Ki-67 was higher than 40% in four patients. Adjuvant chemotherapy was administrated in patients with Ki-67>10%; every patients were treated with radiotherapy and with hormonal therapy too. Although Neuroendocrine breast tumor is considered a distinct entity, the best treatment seems to be correlate to the size of tumor and to the lymph node status and to Ki-67 index like the common breast cancer. KEY WORDS: Diagnosis, Neuroendocrine breast carcinoma.
Asunto(s)
Neoplasias de la Mama/epidemiología , Carcinoma Neuroendocrino/epidemiología , Estrógenos , Neoplasias Hormono-Dependientes/epidemiología , Progesterona , Anciano , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapéutico , Biomarcadores de Tumor/análisis , Neoplasias de la Mama/química , Neoplasias de la Mama/diagnóstico , Neoplasias de la Mama/terapia , Carcinoma Neuroendocrino/química , Carcinoma Neuroendocrino/diagnóstico , Carcinoma Neuroendocrino/terapia , Quimioterapia Adyuvante , Cisplatino/administración & dosificación , Terapia Combinada , Etopósido/administración & dosificación , Femenino , Humanos , Mastectomía/métodos , Persona de Mediana Edad , Proteínas de Neoplasias/análisis , Neoplasias Hormono-Dependientes/química , Neoplasias Hormono-Dependientes/diagnóstico , Neoplasias Hormono-Dependientes/terapia , Radioterapia Adyuvante , Radioterapia de Alta Energía , Receptores de Esteroides/análisis , Estudios Retrospectivos , Biopsia del Ganglio Linfático Centinela , Tamoxifeno/administración & dosificaciónRESUMEN
After extensive mobilization and resection of the left colon, colorectal anastomosis may result impossible due to the distance between the remaining colon and the rectal stump. The Deloyers procedure represents an interesting alternative to total colectomy with ileorectal anastomosis. In this manuscript, we describe when and how to perform this technique with a mini-invasive approach. We also report the case of a patient who underwent Deloyers procedure, due to early ischemia of the descending colon after left colectomy.
