Estimating Unreported COVID-19 Cases with a Time-Varying SIR Regression Model.

BACKGROUND: Potential unreported infection might impair and mislead policymaking for COVID-19, and the contemporary spread of COVID-19 varies in different counties of the United States. It is necessary to estimate the cases that might be underestimated based on county-level data, to take better countermeasures against COVID-19. We suggested taking time-varying Susceptible-Infected-Recovered (SIR) models with unreported infection rates (UIR) to estimate factual COVID-19 cases in the United States. METHODS: Both the SIR model integrated with unreported infection rates (SIRu) of fixed-time effect and SIRu with time-varying parameters (tvSIRu) were applied to estimate and compare the values of transmission rate (TR), UIR, and infection fatality rate (IFR) based on US county-level COVID-19 data. RESULTS: Based on the US county-level COVID-19 data from 22 January (T1) to 20 August (T212) in 2020, SIRu was first tested and verified by Ordinary Least Squares (OLS) regression. Further regression of SIRu at the county-level showed that the average values of TR, UIR, and IFR were 0.034%, 19.5%, and 0.51% respectively. The ranges of TR, UIR, and IFR for all states ranged from 0.007-0.157 (mean = 0.048), 7.31-185.6 (mean = 38.89), and 0.04-2.22% (mean = 0.22%). Among the time-varying TR equations, the power function showed better fitness, which indicated a decline in TR decreasing from 227.58 (T1) to 0.022 (T212). The general equation of tvSIRu showed that both the UIR and IFR were gradually increasing, wherein, the estimated value of UIR was 9.1 (95%CI 5.7-14.0) and IFR was 0.70% (95%CI 0.52-0.95%) at T212. INTERPRETATION: Despite the declining trend in TR and IFR, the UIR of COVID-19 in the United States is still on the rise, which, it was assumed would decrease with sufficient tests or improved countersues. The US medical system might be largely affected by severe cases amidst a rapid spread of COVID-19.

Exploring the Relevance of Green Space and Epidemic Diseases Based on Panel Data in China from 2007 to 2016.

Urban green space has been proven effective in improving public health in the contemporary background of planetary urbanization. There is a growing body of literature investigating the relationship between non-communicable diseases (NCDs) and green space, whereas seldom has the correlation been explored between green space and epidemics, such as dysentery, tuberculosis, and malaria, which still threaten the worldwide situation of public health. Meanwhile, most studies explored healthy issues with the general green space, public green space, and green space coverage, respectively, among which the different relevance has been rarely explored. This study aimed to examine and compare the relevance between these three kinds of green space and incidences of the three types of epidemic diseases based on the Panel Data Model (PDM) with the time series data of 31 Chinese provinces from 2007 to 2016. The results indicated that there exists different, or even opposite, relevance between various kinds of green space and epidemic diseases, which might be associated with the process of urban sprawl in rapid urbanization in China. This paper provides a reference for re-thinking the indices of green space in building healthier and greener cities.