RESUMEN
Background and Aims: Pregnancy-induced hypertension is one of the top three ranked diseases during pregnancy that cause maternal, fetal, and neonatal morbidity and mortality worldwide. To provide adequate information to clinicians and researchers who are striving for potential interventions, biochemical profiling of such patients is required. Methods: A hospital-based case-control study design was conducted from August 2020 to May 2021 to evaluate serum lipid profile, uric acid, and high sensitivity C-reactive protein (hs-CRP) among women with pregnancy-induced hypertension compared to normotensive pregnant women. Data were entered and analyzed using SPSS version 25. Independent t-test and χ 2 were used to compare the relationship of variables between the two groups. A p-value less than 0.05 was used to test statistical significance. Results: The result of this study showed that while the levels (mean ± SD) of serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein-cholesterol (LDL-C), TC/high-density lipoprotein-cholesterol (HDL-C), TG/HDL-C, LDL-C/HDL-C were significantly elevated, HDL-C was decreased among women with pregnancy-induced hypertension than normotensive pregnant women (p < 0.0001). The levels (mean ± SD) of uric acid and hs-CRP were significantly higher among women with pregnancy-induced hypertension compared to normotensive pregnant women (p < 0.0001). Conclusion: This study indicated that pregnancy-induced hypertension women have lipid abnormalities, increased systemic inflammatory markers, and hyperuricemia compared to normotensive pregnant women. Thus, women with PIH showing high dyslipidemia, hyperuricemia, and inflammation are likely to develop hypertension. Therefore, evaluation of these potential biomarkers during early antenatal care services may help seek interventions in PIH.
RESUMEN
Background: Blood banks have been suffering a shortage of blood worldwide due to limited donations. By and large, it is widely believed that blood donation has multiple health benefits. However, there are limited studies that support it. As a result, assessing the biochemical profiles of the regular blood donors is indispensable to evaluating an individual's risk for chronic inflammation. Objective: We strived to compare lipid and haematological profiles of the regular and first-time blood donors in the National Blood Bank Service of Ethiopia. Materials and Methods: A comparative cross-sectional study, involving 104 blood samples (52 each of regular and first-time donors), was designed to analyze lipid and haematological profiles and anthropometric parameters were measured. Data were analyzed using SPSS version 25, Chi-square (χ 2) was used to compare the relationship between categorical variables and an independent Student's t-test was used to compare the mean of the two groups. A p-value <0.05 was considered statistically significant. Results: Regular blood donors had lower mean TC (144.3 ± 28 mg/dL), TG (159.3 ± 88.2 mg/dL), LDL-c (75.9 ± 25.9 mg/dL) than the first-time blood donors with values of TC (158.1 ± 38.94 mg/dL), TG (163.9 ± 82.7 mg/dL), LDL-c (93.1 ± 31.5 mg/dL), respectively. The ratio of LDL-c/HDL-c and TC/HDL-c was found to be lower in regular blood donors when compared to the first-time donors (P < 0.05). Even though the level of HDL-c was higher (39.8 ± 8.8 mg/dL) in regular blood donors compared to first-time blood donors (36.8 ± 7.7 mg/dL), it was not statistically significant. The mean of some haematologic parameters like a platelet, RDW, lymphocyte, and MCH was significantly lower in regular blood donors than in first-time blood donors. BMI and WHR in regular donors were less than the first-time donors, albeit statistically insignificant. Conclusion: Interestingly, blood donation has a significant health benefit by lowering TC, TG and LDL-c, which have the potential risk of developing chronic inflammation.
