[Epitope specificity and protective activity of monoclonal antibodies to Venezuelan equine encephalomyelitis virus]. / Epitopnaia spetsifichnost' i protektivnaia aktivnost' monoklonal'nykh antitel k virusu venesuél'skogo éntsefalomielita loshadei.

Epitope specificity and protective activity of 5 types of monoclonal antibodies (MAB) to strain TM-14 of Venezuelan equine encephalomyelitis (VEE) virus were studied. The competing VEE A4 and VEE B5 MAB were shown to recognize the conformation-dependent epitope of glycoprotein E2 third site and to possess an extremely high protective activity. VEE C6 MAB were active in all the studied biological tests (hemagglutination inhibition, neutralization tests, passive defence) and were directed to glycoprotein E2 site six. Competitive radioimmunoassay demonstrated that VEE A5 MAB also interacted with E2-6 site and by the sum of characteristics detected a new epitope of this site. VEE G1 MAB specific to glycoprotein E1 were characterized by protective, but not neutralizing activity, and competed with MAB to sites E2-2 and E2-6. This means that VEE G1 MAB detect a heretofore not described epitope E1 overlapping with two E2 sites.

[Preparation of water at kidney centers using separating counterosmosis equipment]. / Vodopodgotovka v pochechnykh tsentrakh s ispo'lzovaniem razdeli- te'lnykh obratnoosmoticheskikh apparatov.

A water treatment AKBA-I unit intended for the renal centers was tried. The unit includes a clarifier, an adsorber, a softener, a reflux osmotic separator and electronic systems for the control of hydrodynamic processes. The trials demonstrated the unit to be highly effective as regards the removal from water of salts of hardness, of iron, potassium, oxidizable substances and active chlorine. The pH value of the filtrate (7.1-7.4) appeared to meet the requirements made during the preparation of a dialyzing solution. The concentration of sodium ions in the filtrate was 0.75 mg.eq/l, which did not influence the concentration of sodium ions in the dailyzing solution during its preparation from dry concentrate. During operation of the unit, the selectivity of the APO membrane in the operating mode was defined. It amounted to 85%.