Holocene surface-rupturing paleo-earthquakes along the Kachchh Mainland Fault: shaping the seismic landscape of Kachchh, Western India.

This study explores the seismotectonics of Kachchh in western India, a region with a low-to-moderate strain rate and a history of significant earthquakes, notably the 1819, Mw 7.8 Allah Bund, and the 2001, Mw 7.6 Bhuj. Despite its substantial seismic risk, comprehensive studies on Kachchh's seismogenic sources are scarce. This is attributed to the concealed nature of active structures, hindering definitive age constraints in paleoseismological research. Our research comprises a detailed paleoseismic analysis of the north-verging, reverse Jhura Fault underlying the Jhura anticline, a segment of the Kachchh Mainland Fault. This fault segment shows evidence of surface-rupturing earthquakes in the area south of the Great Rann of Kachchh. The investigation reveals three paleoseismic events: Event I before 9.72 ka B.P., Event II between 8.63-8.20 ka B.P., and Event III between 6.20-6.09 ka B.P. The elapsed time since the last event on this fault is > 8000 years, suggesting that the area is exposed to a significant earthquake hazard. This highlights the need for more precise characterization of individual seismogenic sources for future earthquake preparedness.

Trends in Lung Cancer Incidence and Mortality (1990-2019) in the United States: A Comprehensive Analysis of Gender and State-Level Disparities.

PURPOSE: Lung cancer is the leading cause of cancer-related deaths in the United States. This study aims to analyze lung cancer incidence, mortality, and related statistics from 1990 to 2019, focusing on national- and state-level trends and exploring potential disparities between sexes. METHODS: The Global Burden of Disease database was used to extract tracheal, bronchus, and lung cancer mortality data from 1990 to 2019 for both males and females and across all states of the United States. Age-standardized incidence rates, age-standardized mortality rates, disability-adjusted life years (DALYs), and mortality-to-incidence indices (MIIs) were studied to assess for gender-based, geographic, and temporal disparities. Joinpoint regression analysis was performed to further evaluate trends. RESULTS: The incidence of these cancers in the United States decreased between 1990 and 2019 by 23.35%, with a more significant decline in males (37.73%) than females (1.41%). Similarly, for mortality, a decrease was observed for both sexes combined (26.83%), but much more significantly for males (40.23%) than females (6.01%). The MIIs decreased overall, but there were variations across states. DALYs decreased for both sexes combined, with males experiencing a larger reduction, but an increase was noted in some states for females. CONCLUSION: This analysis reveals diverse trends pertaining to the incidence, mortality, and disability burden associated with lung cancer by sex and states in the United States, emphasizing the need for targeted interventions to reduce disparities. These findings contribute to our understanding of the current landscape of lung cancer and can inform future strategies for prevention, early detection, and management.

Role of Direct Oral Anticoagulation Agents as Thromboprophylaxis in Antiphospholipid Syndrome.

Antiphospholipid syndrome (APS) is an autoimmune disorder that causes venous, arterial and small-vessel thrombosis, pregnancy loss, and premature birth. Cardiac valvular disease, renal thrombotic microangiopathy, thrombocytopenia, hemolytic anemia, and cognitive impairment are some of its other clinical symptoms. Antiphospholipid antibodies cause endothelial cells, monocytes, and platelets to become activated, as well as an increase in tissue factor and thromboxane A2. Complement activation might play a key function in pathogenesis. Long-term oral anticoagulation is used to treat thrombosis, and individuals having arterial episodes should be treated quickly. Patients with systemic lupus erythematosus (SLE), as well as those with solely obstetric antiphospholipid syndrome, should get primary thromboprophylaxis. Obstetric care is based on a combination of medical and obstetric high-risk management, as well as aspirin and heparin therapy. Possible supplementary therapy for this condition is hydroxychloroquine. Statins, rituximab, and novel anticoagulant medicines are all potential future treatments for non-pregnant individuals with antiphospholipid syndrome. We aim to review the role of direct-acting oral anticoagulants (DOACs) as thromboprophylactic drugs in the treatment of APS in this article. The treatment of venous thromboembolism has been transformed by a new class of DOACs. These drugs, such as rivaroxaban, function by inhibiting factor Xa directly. Not only do they have known anticoagulant actions, but they also obviate the need for dosage monitoring and modification, in contrast to warfarin. We conducted an exhaustive literature search of PubMed/MEDLINE and Google Scholar Indexes using the keywords "Antiphospholipid syndrome," "thromboprophylaxis," and "oral anticoagulants" up to September 2021. We found that DOACs have been shown to be non-inferior to warfarin in a variety of anticoagulation situations in a number of high-powered clinical studies. In many hypercoagulable conditions such as APS, DOACs are quickly establishing themselves as first-line therapy. This article is focused on comprehensively reviewing the mechanism of action of DOACs, their role as thromboprophylactic drugs, risks and complications of DOACs, and comparing their efficacy with the standard treatment protocol and warfarin.

Dengue Myocarditis Complicated by COVID-19: A Case Report on Dual Viral Infection.

During the ongoing pandemic of coronavirus disease 2019 (COVID-19), it is crucial for clinicians to have an insight into the emerging co-infections. As the dengue virus (DENV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have related symptomatology, a high index of suspicion is required for prompt diagnosis of concurrent infections involving these two pathogens, especially in the areas endemic for tropical diseases, i.e., dengue fever (DF), malaria, enteric fever, chikungunya, leptospirosis, etc. In this report, we present the case of a middle-aged man from Northern India, who had DF with myocarditis, and was simultaneously found to have COVID-19 co-infection. The patient was managed as per the COVID-19 protocol and had a favorable outcome.

Diabetes Ketoacidosis Complicating as Wrist Drop: A Case Report on Acute Motor Neuropathy.

Diabetic ketoacidosis (DKA) is an acute and major complication of diabetes mellitus. Neurological complications can be seen at any time during the course of illness and range from decreased consciousness to ischemic or hemorrhagic stroke. Acute neuropathy is very rare in this milieu. Here, we report a case of a 40-year-old patient, who developed a left-sided wrist drop after being treated for DKA. The nerve conduction velocity studies demonstrated decreased action potential amplitude in only the motor component of the left radial nerve. Other possible causes of the complaint were ruled out and the patient was managed with cock-up splint, vitamin B1 and B6 supplementation, and physiotherapy. Despite all these measures, the patient had minimal improvement. Thus, close monitoring of patients is crucial to identify these infirmities, even after the acute condition has resolved.

Tsunami records of the last 8000 years in the Andaman Island, India, from mega and large earthquakes: Insights on recurrence interval.

As many as seven tsunamis from the past 8000 years are evidenced by sand sheets that rest on buried wetland soils at Badabalu, southern Andaman Island, along northern part of the fault rupture of the giant 2004 Aceh-Andaman earthquake. The uppermost of these deposits represents the 2004 tsunami. Underlying deposits likely correspond to historical tsunamis of 1881, 1762, and 1679 CE, and provide evidence for prehistoric tsunamis in 1300-1400 CE, in 2000-3000 and 3020-1780 BCE, and before 5600-5300 BCE. The sequence includes an unexplained hiatus of two or three millennia ending around 1400 CE, which could be attributed to accelerated erosion due to Relative Sea-Level (RSL) fall at ~3500 BP. A tsunami in 1300-1400, comparable to the one in 2004, was previously identified geologically on other Indian Ocean shores. The tsunamis assigned to 1679, 1762, and 1881, by contrast, were more nearly confined to the northeast Indian Ocean. Sources have not been determined for the three earliest of the inferred tsunamis. We suggest a recurrence of 420-750 years for mega-earthquakes having different source, and a shorter interval of 80-120 years for large magnitude earthquakes.