Profile of Asphyxial Deaths in Faisalabad: A 10-Year Study.

OBJECTIVE: To determine the frequency of violent asphyxial deaths in Faisalabad over a span of a decade; and assessing the age and gender vulnerability. STUDY DESIGN: Descriptive cross-sectional study. PLACE AND DURATION OF STUDY: Department of Forensic Medicine and Toxicology, Punjab Medical College, Faisalabad, from January 2007 to December 2016. METHODOLOGY: Cases identified as violent asphyxial deaths according to police inquests and findings of the medico-legal examiners were computed. Age, gender, and cause of asphyxia recorded in predesigned proformas and analysed by SPSS version 12.0. RESULTS: Asphyxial deaths accounted for 7.66% (259 / 3,381) of the medico-legal deaths during the 10-year span. Majority (28.57%) victims belonged to the 20-29 year age group, followed by the 10-19 year age group (20.07%). Male victims (56%) outnumbered the females (44%) by ratio of 1.3:1. Ligature strangulation was the cause of asphyxia in majority of the victims (40.93%), followed by hanging (28.96%). CONCLUSION: Young population between 20-29 years were the predominant victims of violent asphyxial deaths. Homicide due to ligature strangulation was the commonest form of violent asphyxial deaths.

Discovery of indole-based tetraarylimidazoles as potent inhibitors of urease with low antilipoxygenase activity.

A series of tetraarylimidazoles (5A-5O) were prepared by one pot four component condensation reactions of 2-arylindole-3-carbaldehydes, substituted anilines, benzil and ammonium acetate in acetic acid. The synthesized compounds exhibited potent antiurease activity with IC50 values ranging from 0.12 ± 0.06 µM to 29.12 ± 0.18 µM as compared with thiourea. However, low inhibition profiles were observed for lipoxygenase. The data show that tetraarylimidazoles containing a substituted 2-penylindole have emerged as a new class of potent inhibitors of urease enzyme.