RESUMEN
Nailfold videocapillaroscopy (NVC) changes in systemic sclerosis (SSc) are correlated with vascular complications, such as pulmonary arterial hypertension (PAH), supporting a potential link between peripheral and internal organ vasculopathy. The current stage of knowledge regarding NVC and PAH is discussed, focusing on the assessment of peripheral microangiopathy and a potential relationship with functional, echocardiographic, and haemodynamic markers of cardiac dysfunction. A comprehensive literature search was carried out to identify all studies focusing on NVC findings in patients with PAH, diagnosed with right heart catheterization. The majority of the studies examined NVC findings in patients with SSc-PAH, while three studies reported NVC abnormalities in patients with idiopathic PAH. Besides the pulmonary vasculature, a systemic component of microangiopathy seems to be involved in PAH. Well-designed prospective trials are warranted to validate NVC as a biomarker, with clinical implications in the diagnostic evaluation, risk stratification, and overall management of PAH in the daily clinical setting.
Asunto(s)
Angioscopía Microscópica/métodos , Enfermedades Vasculares Periféricas/diagnóstico por imagen , Hipertensión Arterial Pulmonar/diagnóstico por imagen , Biomarcadores , Capilares/diagnóstico por imagen , Capilares/fisiopatología , Humanos , Uñas/irrigación sanguínea , Uñas/diagnóstico por imagen , Uñas/fisiopatología , Enfermedades Vasculares Periféricas/fisiopatología , Hipertensión Arterial Pulmonar/fisiopatologíaRESUMEN
We report quantitative neutron scattering measurements of the evolution with doping of the Néel temperature, the antiferromagnetic correlations, and the ordered moment of as-grown, nonsuperconducting Nd(2-x)Ce(x)CuO(4+/-delta) (0=x=0.18). The instantaneous correlation length can be effectively described by our quantum Monte Carlo calculations for the randomly site-diluted nearest-neighbor spin-1/2 square-lattice Heisenberg antiferromagnet. However, quantum fluctuations have a stronger effect on the ordered moment, which decreases more rapidly than for the quenched-disorder model.