GASTROESOPHAGEAL REFLUX DISEASE IN ASSOCIATION WITH LIPID-METABOLIC INDICATORS AT THE YAKUTSK.

AIM: To estimate interrelations of gastroesophageal reflux disease with lipid-metabolic indicators at the Yakutsk. MATERIALS AND METHODS: A one-stage investigation of 100 patients of the Yakut nationality with gastroesophageal reflux disease (GERD) is carried out. For estimating the association of GERD clinical symptoms with lipid-metabolic indicators a method of binary logistical regress with compulsory inclusion of predictors has been used. RESULTS: According to results of the comparison most statistically significant distinctions of metabolic indicators are revealed at GERD esophageal (eructation) and extra-esophageal symptoms (night cough), dyspepsia (distention, epigastric heaviness), as well as snoring. Logistical regression analysis has confirmed interrelation of clinical symptoms with lipid-metabolic indicators, as waist circumference, a level of arterial pressure and blood lipid (triglycerides, lipoprotein cholesterol of low and high density). CONCLUSIONS: Thus, the estimation of interrelation of GERD clinical symptoms with MS criteria at the Yakutsk has revealed the influence of MS components, especially abdominal adiposity, arterial hypertension and triglycerides on the development of dyspepsic symptoms (distention, epigastric heaviness), GERD esophageal (eructation) and extra-esophageal manifestations (night cough).

FEATURES OF CLINICAL-FUNCTIONAL MANIFESTATIONS OF CHRONIC OBSTRUCTIVE LUNG DISEASE IN COMBINATION WITH METABOLIC SYNDROME IN ETHNIC GROUPS OF THE YAKUTS AND THE RUSSIANS.

AIM: Studying features of clinical-functional manifestations of chronic obstructive lung disease in the combination with metabolic syndrome in the Yakut ethnic group. MATERIALS AND METHODS: The basic group consisted of 39 patients of Yakut nationality with chronic obstructive lung disease (COLD) in the combination with metabolic syndrome (MS), middle age of them being 53.4 ± 1.17 years. The comparison group comprised 40 patients of Russian nationality with COLD and MS with middle age 53.1 ± 1.21 years. Features of clinical manifestations and respiratory functions are studied. RESULTS: Cough and sputum were noted in dynamics for 3 years by 64.1% of Yakut patients and 85% of the Russians, p = 0.033; the intensity of cough was marked at 30% of patients of Russian nationality and 15.4% of patients of the Yakut nationality, p = 0.01 6. The morning sputum and daily sputum within 3 months a year at the Russians in comparison with the Yakuts was marked in 95 % vs 74,4 %, p = 0.011; 80.0% vs 56.4% p = 0.024, accordingly. According to Medical Research Council (mMRC) Dyspnea Scale (Mahler et al., 1985) dyspnea has been 2.2 ± 0.09 points atthe Yakuts vs 2.7 ± 0.09 points at Russian, p = 0.002. At patients of the Yakut nationality more often exacerbations were registered 2 times a year (53.8%), at patients of Russian nationality noted 3 times a year (55%). Respiratory function manifestations have been at patients of the Yakut nationality with COLD and MS, in comparison with similar Russian patients: forced expiratory volume for a first second (FEV,) - 64,0+2,30 % vs 56,8?2,69 %, p = 0,026; forced vital capacity of lungs (FVC) - 65,0?2,45 vs 65,0?3,70, p = 0.733; FEV1/FVCL ratio being 102.5 ± 2.81 vs 87.3 ± 3.30, p = 0.000, accordingly. CONCLUSIONS: Regardless of ethnicity the phenotype "D" has higher prevalence rate of clinical phenotype COLD in the combination with metabolic syndrome, thus at the Russians the clinical COLD is characterized by severe clinical manifestations in comparison with theYakuts, and also in both ethnic groups expiratory dysfunctions in the form of decreasing FEV1, decreasing FVC and increases of ratio FEV1/FVC > 70% are marked.