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Defining the subset of mutations in polymerase epsilon (POLE) associated with loss-of-proofreading (LOP) functionality.

Maddalena, G; Zeineddine, F A; Rivero-Hinojosa, S; Aushev, V N; Chowdhury, S; Zeineddine, M A; Yousef, A M; Yap, T A; EINaggar, A C; Liu, M C; White, M; Overman, M J; Kopetz, S; Shen, J P.

Ann Oncol ; 35(7): 678-680, 2024 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-38734075

Asunto(s)

Mutación , Humanos , Proteínas de Unión a Poli-ADP-Ribosa/genética

Genes potentially associated with cisplatin resistance of lung cancer cells.

Kashkin, K N; Musatkina, E A; Komelkov, A V; Tonevitsky, E A; Sakharov, D A; Vinogradova, T V; Kopantsev, E P; Zinovyeva, M V; Favorskaya, I A; Kainov, Ya A; Aushev, V N; Zborovskaya, I B; Tonevitsky, A G; Sverdlov, E D.

Dokl Biochem Biophys ; 438: 147-50, 2011.

Artículo en Inglés | MEDLINE | ID: mdl-21725895

Asunto(s)

Antineoplásicos/farmacología , Cisplatino/farmacología , Resistencia a Antineoplásicos , Neoplasias Pulmonares/genética , Línea Celular Tumoral , Proliferación Celular/efectos de los fármacos , Regulación Neoplásica de la Expresión Génica/efectos de los fármacos , Humanos , Neoplasias Pulmonares/patología

Cytostatic activity of peptide extracts of medicinal plants on transformed A549, H1299, and HeLa Cells.

Tepkeeva, I I; Aushev, V N; Zborovskaya, I B; Demushkin, V P.

Bull Exp Biol Med ; 147(1): 48-51, 2009 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-19526129

RESUMEN

Biological activity of peptide extracts of medicinal plants was studied on transformed non-small-cell lung carcinoma A549 cells, lung cancer H1299 cells, and cervical cancer HeLa cells at various cell densities. Cell survival and proliferation were evaluated 72 h after treatment with extracts in concentrations of 0.05, 0.25, and 0.5 microg/microl. The cytostatic effect was produced by peptide extracts of Camelia sinesis Kuntze, Inonotus obliquus, and a mixture Inula helenium L., Chelidonium majus L., Equisetum arvense L., and Inonotus obliquus. Peptide extracts of Hypericum perforatum L. and Laurus nobilis L. in the same concentrations had no effects on proliferative activity and growth of tumor cells.

Asunto(s)

Péptidos/farmacología , Extractos Vegetales/farmacología , Plantas Medicinales/química , Línea Celular Transformada , Humanos , Especificidad de la Especie

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