[ЕFFICACY OF BIOMECHANICALLY SUBSTANTIATED METHODS OF MOBILIZATION OF ADIPOSO-CUTANEOUS FLAPS FROM THE ANTERIOR ABDOMINAL WALL].

There were studied the skin specimen from 40 dead persons, aged from 23 to 87 yrs, (52 ± 15.6) yrs at average, with the objective to investigate the biochemical properties and establishment of experimental deformation angles. Basing on the biomechanical tissues background of the anterior abdominal wall topographo-anatomic regions there were analyzed the results of treatment in the patients, оperated on for the anterior wall deformities and defects, concerning biomechanical possibilities of the flaps and classic methods of the tissues mobilization applied. There was established, that in borders of possible plastic deformity the tissues pressure distribution have persisted in normal range, and this have promoted the cicatricial tissue formation, which did not differ in characteristics from the adjacent connective tissues structures, what have had guaranteed the uncomplicated course of the wound process. Biomechanical properties of adiposo-cutaneous flaps must be taken into account while manipulating with them with the objective of obtaining an optimal distribution of pressure along the flaps and conditions for obtaining of the tissues adequate reaction on operative trauma, while performing interventions on the anterior abdominal wall for its defects and deformities, guaranteeing better esthetic result of treatment, reduction of postoperative morbidity and stationary stay.

[CLINICAL CHARACTERISTIC OF POSTOPERATIVE STATE OF CICATRICIALLY-CHANGED CUTANEOUS TISSUES].

Abstract Comparison of postoperative kinds of cicatrix was conducted in 60 patients, depending on the suture material applied. Best conditions for the operative wound healing, achievement of more esthetic normotrophic cicatrix were guaranteed by application of a cutaneous adhesive.

[PECULIARITIES OF ISOLATION AND MOBILIZATION OF ADIPOSE­CUTANEOUS FLAPS OF A NIPPLE­LIKE AREA WHILE PERFORMING LOWER RITIDECTOMY, TAKING INTO ACCOUNT PECULIARITIES OF THE SKIN BIOMECHANICS].

Procedure of lower ritidectomy performance, taking into account analysis of parameters of the adipose/cutaneous flaps stretching and relaxation, was improved. Results of treatment of 30 patients, suffering involution ptosis of facial lower third, were analyzed. In 15 of them lower ritidectomy, using results of biochemical and morphological investigations, was conducted, and 15 were operated on in accordance to routine methods.

[PECULIARITIES OF ISOLATION AND MOBILIZATION OF ADIPOSE­CUTANEOUS FLAPS OF A NIPPLE­LIKE AREA WHILE PERFORMING LOWER RITIDECTOMY, TAKING INTO ACCOUNT PECULIARITIES OF THE SKIN BIOMECHANICS].

Procedure of lower ritidectomy performance, taking into account analysis of parameters of the adipose/cutaneous flaps stretching and relaxation, was improved. Results of treatment of 30 patients, suffering involution ptosis of facial lower third, were analyzed. In 15 of them lower ritidectomy, using results of biochemical and morphological investigations, was conducted, and 15 were operated on in accordance to routine methods.

[STUDYING OF BIOMECHANICAL PROPERTIES OF SKIN IN THE MASTOID REGION WHILE THE COSMETIC OTOPLASTY PERFORMANCE].

The present methods for a droopy ears correction do not guarantee the optimal cosmetic effect achievement. Optimal borders of deformity in cutaneo-adiposal flap of the mastoid region while cosmetic otoplasty performance were studied. Basing on analysis of biomechanical investigations, there were determined the optimal corners of stretching and direction of the strength vector in cutaneo-adiposal flaps while otoplasty performance, securing conditions for surgical intervention performance with preservation of a natural topographo-anatomical ratios in the head and neck tissues.

[BIOMECHANICAL SUBSTANTIATION OF ONE-AXIS DEFORMITY OF ADIPOSE-CUTANEOUS FLAPS OF TEMPORAL AND ZYGOMATIC AREAS WHILE PERFORMANCE OF UPPER RHYTIDOPLASTY].

The urgency of the problem of determining the biomechanical features adipose-cutaneous grafts due to a significant increase in the frequency of performing cosmetic surgery and the lack of a unified concept for such interventions. In 32 women aged 35 to 65 years, which will eliminate the excess soft tissues in the implementation ritidectomy and other surgical interventions, isolated patches of adipose-cutaneous flaps to determine the mechanisms of its plastic deformation. Based on the analysis of biomechanical research targeted the optimal stretching the boundaries of adipose-cutaneous flaps zygomatic--to (0.45 ± 0.021) cm and temporal--by (0.0165 ± 0.002) cm refer to areas that allowed to perform surgery with preservation of natural topographoanatomic relations persons in the performance of the upper ritidectomy.

[Dynamics of clinical changes and healing of purulent wounds in application of nanocapsules of phosphatidylcholine in complex of treatment of patients, suffering the oral cavity floor phlegmon].

Substantiation of expediency for nanocapsules of phosphatidylcholine (lipin) application, owing antihypoxant, antioxydant and immunostimulating action in complex of treatment of patients, suffering odontogenic phlegmon of oral cavity floor (OPHOCF), is presented. The preparation application have promoted a trustworthy reduction of exudation of purulent content, as well as more rapid occurrence of granulations and the wound epithelization.

[Changes in clinical indices in patients in predisposition for pathological cicatrices formation].

Prophylaxis of ocurrence of pathological cutaneous cicatrices is one of actual problems of plastic surgery of head and neck. Cicatricial changes of tissues, as a consequence of operative interventions and various damaging causes (mechanical, thermal and chemical impact, ionizing irradiation, deep destructive inflammation), were depicted. Propensity for formation of pathological cicatrices we consider as the organism state, in which cicatricial changes occur as an answer for minimal trauma or spontaneously. Detailed analysis of fundamental issues and periodical scientific publications witness the insufficient substantiation of this issue.

[Modifications of chemical composition of blood serum in chronic nitrate intoxication (experimental research)].

Nitrates (salts of nitric acid) are very common substances in nature and are present in almost all living organisms. Relevance of research about features of various pathological processes in chronic nitric intoxication significantly associated with the fact that the intake of nitro compounds has significantly increased in recent years, especially in rural areas where local water sources are used. Investigations were carried out on 20 white Wistar rats. Two series of the experiment ware held: Group I - intact animals (10 animals); Group II - animals after administration of sodium nitrate at a dose of 200 mg/kg in the form of an aqueous solution intragastrically for 60 days (10 animals). Chronic nitrate intoxication leads to a significant increase of the level of serum chondroitin rats with permanent indicators glycoproteins indicates that the products disorganization of proteoglycans from the bone to the blood serum. Increasing of overall level glycosaminoglycans and the third fraction (heparan sulfate), and reducing of the 2-nd fraction (chondroitin-4-sulfate) glycosaminoglycans in serum may be indicative of a chronic lesion of sodium nitrite intoxication general connective tissue (including bone tissues and liver parenchymal).

[Clinico-morphological substantiation of feasibility of angiosomic adipose-cutaneous flaps from temporal and parietal regions application].

Actuality of the problem, consisting of restoration of defects and deformity zones on head and neck, is caused by great quantity of patients, surgical treatment of which constitute important medico-social problem. The flaps, raised from temporal and parietal regions, are considered perspective for replacement of defects and the deformity zones on head and neck. But, for their correct isolation and mobilization it is necessary to know the topographoanatomical peculiarities of superficial temporal artery, localization of which differs, depending on the head form. The methods of isolation and mobilization of angiosomic preauricular, postauricular and fascial temporal-parietal flaps were optimized in the clinic, basing on analysis of results of the investigations performed and computeric modeling of the superficial temporal artery branches.

[The risk factors and analysis of complications after regenerative interventions in surgery of oral cavity].

Most spreaded risk factors in reconstructive and plastic surgery of oral cavity were analyzed. Trustworthy monitoring of rate of the complications occurrence in augmentation of the jaws bones was conducted, depending on the risk factor.

[Comparative description and retrospective analisis of modern methods of surgical wounds closure for intraoperative prophylaxis of development of pathologic cutaneous cicatrices].

The experience of application of various methods of closure was presented for the head and neck cutaneous wound surfaces after elective operative interventions. The variant of the postoperative results estimation and optimization of the wounds healing by primary closure was proposed.

[Incidence of odontogenic phlegmon associated with polymorphic variant 896A/G of gene TLR4, but not with 2258G/A of gene TLR2].

The problem actuality is caused by significant enhancement of the incidence rate for inflammatory diseases of the head and neck tissues, first of all of the oral cavity floor abscesses and phlegmons, which causes severe forms of mediastinitis while inadequate treatment. The authors have had established, that Toll-like receptors (TLR) initiate a cascade of anti-inflammatory reactions of the inborn immunity, followed by synthesis of a certain cytokines, and their genetic polymorphism changes the immune reactivity of the organism. Trustworthy correlation of the gene TLR4 (rs4986790) polymorphism 896A/G was proved with high risk of the odontogenic phlegmon of the oral cavity floor occurrence, what would permit to prognosticate the disease course in early terms, to optimize the schemes of its prophylaxis and treatment.

[THE ROLE OF ANTIHYPOXANTS AND ANTIOXIDANT IN TREATMENT OF ODONTOGENIC OF MAXILLOFACIAL AREA].

The aim of this work is the systematization of the literature data for the most clearly defined directions of study of the effectiveness of antioxidant and antihypoxant drugs in complex treatment of patients with purulent inflammatory diseases of the maxillofacial area. The authors attempt to analyze the results of the use of antioxidant and antihypoxant therapy at pyoinflammatory pro- cesses of different localization. Areas of research of the impact of antioxidant and antihypoxants therapy on physical and biochemical parameters of the maxillofacial area and the organism of the patient as a whole are defined.

[Analysis of morbidity and state of diagnostics of malignant neoplasms of maxillofacial localization (based on materials from Poltava region)].

In the article information is resulted about morbidity by malignant new formations of maxillofacial localization in region of Poltava for 20 years of supervisions, which diminished from 4 to 2,5% to 2011 year, but increased to 3,3% in the structure of general oncologic morbidity in 2012; about the change of structure and grade places of oncostomatology's morbidity; about establishment of reasons of late diagnostics. It is suggested to continue the study of monitoring of malignant new formations of maxillofacial localization of population and level of motivation of providing of the specialized help a population with the obligatory analysis of information; to count the indexes of timely diagnostics of shrine one of basic criteria of estimation of activity of stomatological service; to oblige doctors--necessarily to pass stomatologies courses of the in-plant training on oncology 1 time in 5 years.