RESUMEN
Animals are inherently motivated to explore social novelty cues over familiar ones, resulting in a novelty preference (NP), although the behavioral and circuit bases underlying NP are unclear. Combining calcium and neurotransmitter sensors with fiber photometry and optogenetics in mice, we find that mesolimbic dopamine (DA) neurotransmission is strongly and predominantly activated by social novelty controlling bout length of interaction during NP, a response significantly reduced by familiarity. In contrast, interpeduncular nucleus (IPN) GABAergic neurons that project to the lateral dorsal tegmentum (LDTg) were inhibited by social novelty but activated during terminations with familiar social stimuli. Inhibition of this pathway during NP increased interaction and bout length with familiar social stimuli, while activation reduced interaction and bout length with novel social stimuli via decreasing DA neurotransmission. These data indicate interest towards novel social stimuli is encoded by mesolimbic DA which is dynamically regulated by an IPNâLDTg circuit to control NP.
Asunto(s)
Dopamina , Núcleo Interpeduncular , Ratones , Animales , Dopamina/metabolismo , Tegmento Mesencefálico/metabolismo , Núcleo Interpeduncular/metabolismo , Transmisión Sináptica , Neuronas GABAérgicas/metabolismoRESUMEN
Retinal ganglion cell (RGC) types relay parallel streams of visual feature information. We hypothesized that neuromodulators might efficiently control which visual information streams reach the cortex by selectively gating transmission from specific RGC axons in the thalamus. Using fiber photometry recordings, we found that optogenetic stimulation of serotonergic axons in primary visual thalamus of awake mice suppressed ongoing and visually evoked calcium activity and glutamate release from RGC boutons. Two-photon calcium imaging revealed that serotonin axon stimulation suppressed RGC boutons that responded strongly to global changes in luminance more than those responding only to local visual stimuli, while the converse was true for suppression induced by increases in arousal. Converging evidence suggests that differential expression of the 5-HT1B receptor on RGC presynaptic terminals, but not differential density of nearby serotonin axons, may contribute to the selective serotonergic gating of specific visual information streams before they can activate thalamocortical neurons.
Asunto(s)
Cuerpos Geniculados , Receptor de Serotonina 5-HT1B , Serotonina , Tálamo , Animales , Ratones , Axones/fisiología , Calcio , Cuerpos Geniculados/fisiología , Receptor de Serotonina 5-HT1B/metabolismo , Células Ganglionares de la Retina/fisiología , Serotonina/metabolismo , Tálamo/fisiologíaRESUMEN
A total of 2,162,400 adults were incarcerated in the United States in 2016. Sub-optimal health status, existing healthcare disparities, and fragmented healthcare delivery among incarcerated populations are concerning and warrant redress. This article highlights the need for and discusses the benefits of collaboration between healthcare professionals in incarcerated settings. The roles of primary care health professionals, pharmacists, and medical family therapists (MedFTs) in correctional facilities are outlined. Through integrated healthcare models, enhanced communication, improved continuity of care, and holistic treatment plans, existing gaps in healthcare delivery in correctional facilities can be filled. By working together and assuming nontraditional roles, medical professionals can help improve health outcomes of incarcerated individuals. Collaborative healthcare models in incarcerated settings can elevate public health in a cost-effective, yet positive manner.
Asunto(s)
Atención a la Salud , Prisioneros , Adulto , Humanos , Estados Unidos , Comunicación , Estado de Salud , Instalaciones CorreccionalesRESUMEN
INTRODUCTION: Incarcerated fathers and their coparenting partners experience serious challenges to their health and well-being, beyond the general population. The interdependent nature of romantic involvement and coparenting a child suggests that self-reported mental health and the perceived consensus of the coparenting relationship may predict the physical health of not only the individual, but their partner. METHOD: We use Actor-Partner Interdependence Modeling (APIM) for 483 romantically involved coparents from the Multisite Family study on Incarceration, Parenting, and Partnering to explore this link. Each dyad consists of an incarcerated male and a nonincarcerated female. RESULTS: Results indicate a significant link between mental and physical health for each dyad member (actor effects). Additionally, a partner effect links perceived consensus of coparenting from men to women, indicating that women whose partners reported a higher perceived consensus of coparenting also reported better physical health. DISCUSSION: Implications for marriage and family therapy, criminal justice, health, and human services policy are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).