How should dysphagia care of older adults differ? Establishing optimal practice patterns.

An unprecedented demographic transformation is occurring as our population ages. Those older than age 65 represent the fastest growing segment of the population. Within this older group, approximately 10% to 30% of adults are estimated to have dysphagia, but true incidence and prevalence are unknown. They make up a heterogeneous mix of both healthy and disabled individuals that reside across a spectrum of living settings. As clinicians approach older adults with dysphagia, general geriatric principles should be followed to optimize care for this diverse group. Likewise, practitioners need to appreciate the physiology that distinguishes a healthy old swallow from dysphagia and acknowledge the wide array of causes that contribute to dysphagia in older people. Clinicians need to recognize the heterogeneity in health, functional abilities, social supports, and resources among the elderly and understand how these factors may influence approaches to dysphagia in different care settings. Standard outcome measures of pneumonia, malnutrition, and mortality must be blended with other quality of life indices. Advanced directives are essential in caring for elderly patients with dysphagia irrespective of their health acuity or care setting. Ultimately, patient and family preferences should dictate the swallowing and feeding interventions offered.

Effects of estrogen replacement therapy on the circadian rhythms of serum cortisol and body temperature in postmenopausal women.

Estrogen replacement therapy (ERT) seems to enhance longevity in women. Both gender and aging have been shown to influence the regulation of circadian rhythms, yet little is known about the effect of ERT on circadian regulation. The aim of this study was to determine the effects of ERT (oral conjugated estrogen: Premarin, 0.625 mg) for 6-8 weeks on circadian serum cortisol by continuous blood sampling every 15 min for 24 h with simultaneous measurements of body temperature in six healthy postmenopausal women (range, 54-61 years). The results are presented as median values (range in quartiles). The circadian amplitude of cortisol increased during ERT from 20.20 (18.35, 23.61) to 25.97 (24.94, 27.74) microg/dL (p = 0.016), whereas the timing of nocturnal nadir and morning acrophase did not differ significantly. ERT lowered the 24-h body temperature from 37.03 degrees C (36.95 degrees C, 37.07 degrees C) to 36.90 degrees C (36.77 degrees C, 36.97 degrees C) (p = 0.038), but did not alter the peak and trough body temperatures significantly. These findings are noteworthy because the increased circadian amplitude of serum cortisol during ERT contrasts with the reduction in circadian amplitude seen with normal aging. The reduction in body temperature confirms the regulatory effect of ERT in thermoregulation and has implications regarding the correlation between basal metabolic rate and life span.